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Serlopitant

Names

[ CAS No. ]:
860642-69-9

[ Name ]:
Serlopitant

[Synonym ]:
UNII-277V92K32B
Serlopitant

Biological Activity

[Description]:

Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease

[Target]

Neurokinin-1 receptor[1]


[References]

[1]. Yosipovitch G, et al. Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial. J Am Acad Dermatol. 2018 May;78(5):882-891.


[Related Small Molecules]

Substance P acetate salt | rolapitant | SB-222200 | Fezolinetant | Netupitant | [Sar9,Met(O2)11]-Substance P TFA | MLE-4901 | Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) | Maropitant | NKP608 | Talnetant | Y1 receptor antagonist 1 | [bAla8]-Neurokinin A(4-10) | Befetupitant

Chemical & Physical Properties

[ Molecular Formula ]:
C29H28F7NO2

[ Molecular Weight ]:
555.52700

[ Exact Mass ]:
555.20100

[ PSA ]:
29.54000

[ LogP ]:
7.61980

Related Compounds

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