(β-Ala8)-Neurokinin A (4-10)

Names

[ Name ]:
(β-Ala8)-Neurokinin A (4-10)

[Synonym ]:
Asp-Ala-Phe-Val-|A-Ala-Leu-Met-NH2
[Ala5,|A-Ala8]-|A-Neurokinin Fragment 4-10

Biological Activity

[Description]:

(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vivo]

(β-Ala8)-Neurokinin A (4-10) (2 μg/kg; i.v.) increases colonic tone in conscious female dogs[2].

[References]

[1]. C A Maggi, et al. In vivo pharmacology of [beta Ala8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur J Pharmacol. 1990 Feb 20;177(1-2):81-6.

[2]. G Basilisco, et al. A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10). Aliment Pharmacol Ther. 1994 Oct;8(5):527-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₅₆N₈O₉S

[ Molecular Weight ]:
764.93200

[ Exact Mass ]:
764.38900

[ PSA ]:
306.31000

[ LogP ]:
2.66780

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Analogs of neurokinin A(4-10) afford protection against gastroduodenal ulcers in rats.

Peptides 11 , 293-297, (1990)

We have developed a novel series of peptides, related to the NKA(4-10) sequence, in which substitution of selected amino acids determined variations in the affinity for the TK receptor subtypes. Subcu...

Tachykinin-induced responses via neurokinin-1 and -3 receptors in hamster submandibular ganglion neurones.

Arch. Oral Biol. 44 , 455-463, (1999)

Both substance P and neurokinin A are known as neurotransmitters of the submandibular ganglion cell. In this study, the effects of neurokinin (NK) receptor-subtype agonists on hamster submandibular ga...

Related Compounds

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