PknB-IN-1

Modify Date: 2025-08-22 06:48:50

PknB-IN-1 structure	Common Name	PknB-IN-1
	CAS Number	1447917-39-6	Molecular Weight	390.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₀N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PknB-IN-1

PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL)[1].

Name	PknB-IN-1

Description	PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL)[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 14.4 μM (PknB)[1]
In Vitro	PknB-IN-1 (0-100 μM; 60 min) can inhibit M. tuberculosis PknB activity[1]. Cell Viability Assay[1] Cell Line: M. tuberculosis Concentration: 0-100 μM Incubation Time: 60 min Result: Exhibited M. tuberculosis PknB inhibition activity (IC50=7.3 μM).
References	[1]. Paptawan Thongdee, et al. Virtual Screening Identifies Novel and Potent Inhibitors of Mycobacterium tuberculosis PknB with Antibacterial Activity. J Chem Inf Model. 2022 Aug 22.

Molecular Formula	C₂₅H₃₀N₂O₂
Molecular Weight	390.52

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