PknB-IN-1

Names

[ Name ]:
PknB-IN-1

Biological Activity

[Description]:

PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL)[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 14.4 μM (PknB)[1]

[In Vitro]

PknB-IN-1 (0-100 μM; 60 min) can inhibit M. tuberculosis PknB activity[1]. Cell Viability Assay[1] Cell Line: M. tuberculosis Concentration: 0-100 μM Incubation Time: 60 min Result: Exhibited M. tuberculosis PknB inhibition activity (IC50=7.3 μM).

[References]

[1]. Paptawan Thongdee, et al. Virtual Screening Identifies Novel and Potent Inhibitors of Mycobacterium tuberculosis PknB with Antibacterial Activity. J Chem Inf Model. 2022 Aug 22.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₀N₂O₂

[ Molecular Weight ]:
390.52

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.