DUBs-IN-1

Names

[ CAS No. ]:
924296-18-4

[ Name ]:
DUBs-IN-1

[Synonym ]:
DUBs-IN-1

Biological Activity

[Description]:

DUBs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.24 μM for USP8.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

Research Areas >> Cancer

[Target]

IC50: 0.24 μM (USP8)[1]

[In Vitro]

DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8. DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM[1].

[References]

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.

[Related Small Molecules]

BAY 11-7082 | P5091 | PR-619 | VLX1570 | Degrasyn(WP1130) | P 22077 | DUBs-IN-2 | ML364 | NSC 687852 | GNE-6776 | ML 323 | HBX 19818 | IU1 | LDN-57444

Chemical & Physical Properties

[ Density]:
1.32g/cm3

[ Boiling Point ]:
632.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₁N₅O

[ Molecular Weight ]:
337.33400

[ Flash Point ]:
336.2ºC

[ Exact Mass ]:
337.09600

[ PSA ]:
94.95000

[ LogP ]:
3.16956

[ Index of Refraction ]:
1.704

Related Compounds

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