LDN-57444
Names
[ CAS No. ]:
668467-91-2
[ Name ]:
LDN-57444
[Synonym ]:
(3Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)-1,3-dihydro-2H-indol-2-one
3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)-1,3-dihydro-2H-indol-2-one
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)
1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime), (3Z)-
LDN-57444
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 0.88 μM (UCH-L1), 25 μM (UCH-L3)[1] Ki: 0.40 μM (UCH-L1)[1]
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
534.4±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C17H11Cl3N2O3
[ Molecular Weight ]:
397.640
[ Flash Point ]:
277.0±32.9 °C
[ Exact Mass ]:
395.983521
[ PSA ]:
58.97000
[ LogP ]:
4.70
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.655
[ Storage condition ]:
Desiccate at +4°C
[ Water Solubility ]:
DMSO: soluble16mg/mL
Safety Information
[ Symbol ]:
GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H410
[ Precautionary Statements ]:
P273-P501
[ Hazard Codes ]:
N
[ Risk Phrases ]:
50/53
[ Safety Phrases ]:
60-61
[ RIDADR ]:
UN 3077 9 / PGIII
Articles
J. Cell. Mol. Med. 18(11) , 2252-65, (2014)
The tumour suppressor activity of the phosphatase and tensin homologue on chromosome 10 (PTEN) is subject of intense investigative efforts, although limited information on its regulation in breast can...
Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair.Cell Cycle 14(7) , 1103-15, (2015)
Xeroderma pigmentosum group G (XPG) protein is a structure-specific repair endonuclease, which cleaves DNA strands on the 3' side of the DNA damage during nucleotide excision repair (NER). XPG also pl...
NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib.Oncotarget 6 , 9807-19, (2015)
There is accumulating evidence that TrkA and its ligand Nerve Growth Factor (NGF) are involved in cancer development. Staurosporine derivatives such as K252a and lestaurtinib have been developed to bl...