LDN-57444
LDN-57444 structure
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Common Name | LDN-57444 | ||
|---|---|---|---|---|
| CAS Number | 668467-91-2 | Molecular Weight | 397.640 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 534.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H11Cl3N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 277.0±32.9 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells.
J. Cell. Mol. Med. 18(11) , 2252-65, (2014) The tumour suppressor activity of the phosphatase and tensin homologue on chromosome 10 (PTEN) is subject of intense investigative efforts, although limited information on its regulation in breast cancer is available. Herein, we report that, in breast cancer ... |
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Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair.
Cell Cycle 14(7) , 1103-15, (2015) Xeroderma pigmentosum group G (XPG) protein is a structure-specific repair endonuclease, which cleaves DNA strands on the 3' side of the DNA damage during nucleotide excision repair (NER). XPG also plays a crucial role in initiating DNA repair synthesis throu... |
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NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib.
Oncotarget 6 , 9807-19, (2015) There is accumulating evidence that TrkA and its ligand Nerve Growth Factor (NGF) are involved in cancer development. Staurosporine derivatives such as K252a and lestaurtinib have been developed to block TrkA kinase signaling, but no clinical trial has fully ... |
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Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Briq. Essential Oil.
J. Oleo Sci. 64 , 869-79, (2015) Allium roseum L. (Alliaceae) endemic mediterranean specie was represented in the North Africa by 12 different taxa. In the present study, chemical composition, antiproliferative, antioxidant and antimicrobial activities of the essential oil extracted from A. ... |
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Development of surface plasmon resonance imaging biosensors for detection of ubiquitin carboxyl-terminal hydrolase L1.
Anal. Biochem. 469 , 4-11, (2014) We have developed a new method for highly selective determination of the ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) concentration using a surface plasmon resonance imaging (SPRI) technique and two different biosensors. UCH-L1 was captured from a soluti... |
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RESOLFT nanoscopy with photoswitchable organic fluorophores.
Sci. Rep. 5 , 17804, (2015) Far-field optical nanoscopy has been widely used to image small objects with sub-diffraction-limit spatial resolution. Particularly, reversible saturable optical fluorescence transition (RESOLFT) nanoscopy with photoswitchable fluorescent proteins is a powerf... |
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GC-MS Based Plasma Metabolomics for Identification of Candidate Biomarkers for Hepatocellular Carcinoma in Egyptian Cohort.
PLoS ONE 10 , e0127299, (2015) This study evaluates changes in metabolite levels in hepatocellular carcinoma (HCC) cases vs. patients with liver cirrhosis by analysis of human blood plasma using gas chromatography coupled with mass spectrometry (GC-MS). Untargeted metabolomic analysis of p... |
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Comparison of Aroma-Active Volatiles in Oolong Tea Infusions Using GC-Olfactometry, GC-FPD, and GC-MS.
J. Agric. Food Chem. 63 , 7499-510, (2015) The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma intensity (AI) was employed to investigate the aroma-active comp... |
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Determination of 2-Methylimidazole, 4-Methylimidazole, and 2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in Licorice Using High-Performance Liquid Chromatography-Tandem Mass Spectrometry Stable-Isotope Dilution Analysis.
J. Agric. Food Chem. 63 , 5930-4, (2015) A quick and selective analytical method was developed for the simultaneous quantitation of 2-methylimidazole, 4-methylimidazole, and 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole, which are known to be formed by Maillard reactions. The methodology reported ... |
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Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium).
Fitoterapia 100 , 95-109, (2015) In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Islands where they are traditionally used as diuretic, wound ... |