DUBs-IN-2
Names
[ CAS No. ]:
924296-19-5
[ Name ]:
DUBs-IN-2
[Synonym ]:
9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
DUBs-IN-2
Biological Activity
[Description]:
DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.
[Related Catalog]:
[Target]
IC50: 0.28 μM (USP8)[1]
[In Vitro]
DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].
[References]
[Related Small Molecules]
BAY 11-7082
|
P5091
|
PR-619
|
VLX1570
|
Degrasyn(WP1130)
|
P 22077
|
ML364
|
NSC 687852
|
GNE-6776
|
ML 323
|
HBX 19818
|
IU1
|
LDN-57444
|
USP7/USP47 inhibitor
Chemical & Physical Properties
[ Density]:
1.36±0.1 g/cm3 (20 °C, 760 mmHg)
[ Boiling Point ]:
555.7±60.0 °C (760 mmHg)
[ Molecular Formula ]:
C15H9N5O
[ Molecular Weight ]:
275.26500
[ Exact Mass ]:
275.08100
[ PSA ]:
94.95000
[ LogP ]:
1.98926