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1447917-39-6

1447917-39-6 structure

1447917-39-6 structure

Name: PknB-IN-1
Chemical Name: PknB-IN-1
CAS Number: 1447917-39-6
Molecular Formula: C₂₅H₃₀N₂O₂
Molecular Weight: 390.52
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-10-15 21:32:48
Modify Date: 2025-08-22 06:48:50
PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL)[1].

Name	PknB-IN-1

Description	PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC50=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL)[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 14.4 μM (PknB)[1]
In Vitro	PknB-IN-1 (0-100 μM; 60 min) can inhibit M. tuberculosis PknB activity[1]. Cell Viability Assay[1] Cell Line: M. tuberculosis Concentration: 0-100 μM Incubation Time: 60 min Result: Exhibited M. tuberculosis PknB inhibition activity (IC50=7.3 μM).
References	[1]. Paptawan Thongdee, et al. Virtual Screening Identifies Novel and Potent Inhibitors of Mycobacterium tuberculosis PknB with Antibacterial Activity. J Chem Inf Model. 2022 Aug 22.

Molecular Formula	C₂₅H₃₀N₂O₂
Molecular Weight	390.52

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