Propofol-d17

Modify Date: 2024-01-10 12:18:21

Propofol-d17 structure	Common Name	Propofol-d17
	CAS Number	1261393-54-7	Molecular Weight	195.376
	Density	0.9±0.1 g/cm3	Boiling Point	256.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₂HD₁₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	107.5±7.2 °C

Use of Propofol-d17

Propofol-d17 (2,6-Diisopropylphenol-d17) is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].

Name	2,6-Bis[(2H7)-2-propanyl](2H3)phenol
Synonym	More Synonyms

Description	Propofol-d17 (2,6-Diisopropylphenol-d17) is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid(A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282(3):1181-6.

Density	0.9±0.1 g/cm3
Boiling Point	256.0±0.0 °C at 760 mmHg
Molecular Formula	C₁₂HD₁₇O
Molecular Weight	195.376
Flash Point	107.5±7.2 °C
Exact Mass	195.242477
LogP	4.16
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.513

2,6-Bis[(2H7)-2-propanyl](2H3)phenol

Phenol-3,4,5-d3, 2,6-bis[1-(methyl-d3)ethyl-1,2,2,2-d4]-

Propofol-d17

Use of Propofol-d17

Names

Propofol-d17 Biological Activity

Chemical & Physical Properties

Synonyms