100326-46-3

100326-46-3 structure

Name: Tempol-d17
Chemical Name: 3,3,4,5,5-pentadeuterio-1-λ1-oxidanyl-2,2,6,6-tetrakis(trideuteriomethyl)piperidin-4-ol
CAS Number: 100326-46-3
Molecular Formula: C₉HD₁₇NO₂
Molecular Weight: 189.350
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-02-26 08:00:00
Modify Date: 2024-01-11 19:29:00
Tempol-d17 is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].

Name	3,3,4,5,5-pentadeuterio-1-λ1-oxidanyl-2,2,6,6-tetrakis(trideuteriomethyl)piperidin-4-ol
Synonyms	{4-Hydroxy-2,2,6,6-tetrakis[(H)methyl](H)-1-piperidinyl}oxidanyl 4-Hydroxy-TEMPO-d17 TEMPOL-d17 4-hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl {4-Hydroxy-2,2,6,6-tetrakis[(H)methyl](H)piperidin-1-yl}oxidanyl <2H17>4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl 1-Piperidinyl-3,3,4,5,5-d-oxy, 4-hydroxy-2,2,6,6-tetra(methyl-d)- MFCD00190466

Description	Tempol-d17 is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947. [3]. Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug58(2):658-73.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	3