Tempol-d17

Modify Date: 2024-01-11 19:29:00

Tempol-d17 structure	Common Name	Tempol-d17
	CAS Number	100326-46-3	Molecular Weight	189.350
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉HD₁₇NO₂	Melting Point	69-71ºC(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Tempol-d17

Tempol-d17 is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].

Name	3,3,4,5,5-pentadeuterio-1-λ1-oxidanyl-2,2,6,6-tetrakis(trideuteriomethyl)piperidin-4-ol
Synonym	More Synonyms

Description	Tempol-d17 is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947. [3]. Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug58(2):658-73.

Melting Point	69-71ºC(lit.)
Molecular Formula	C₉HD₁₇NO₂
Molecular Weight	189.350
Exact Mass	189.240463
PSA	23.47000
LogP	1.28370

Tempol-d17 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	3

{4-Hydroxy-2,2,6,6-tetrakis[(H)methyl](H)-1-piperidinyl}oxidanyl

4-Hydroxy-TEMPO-d17

TEMPOL-d17

4-hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl

{4-Hydroxy-2,2,6,6-tetrakis[(H)methyl](H)piperidin-1-yl}oxidanyl

<2H17>4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl

1-Piperidinyl-3,3,4,5,5-d-oxy, 4-hydroxy-2,2,6,6-tetra(methyl-d)-

MFCD00190466

Tempol-d17

Use of Tempol-d17

Names

Tempol-d17 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms