90429-66-6

90429-66-6 structure
90429-66-6 structure
  • Name: Tempol-d17,15N
  • Chemical Name: 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (d17, 15n)
  • CAS Number: 90429-66-6
  • Molecular Formula: C9HD17NO2
  • Molecular Weight: 190.34300
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2018-03-10 08:00:00
  • Modify Date: 2024-01-10 09:42:56
  • Tempol-d17,15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].

Name 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (d17, 15n)
Description Tempol-d17,15N is the deuterium labeled Tempol[1]. Tempol is a general superoxide dismutase (SOD)-mimetic drug that efficiently neutralizes reactive oxygen species (ROS)[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Vilar-Pereira G, et al. Resveratrol Reverses Functional Chagas Heart Disease in Mice. PLoS Pathog. 2016 Oct 27;12(10):e1005947.  

[3]. Chatterjee PK, et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 2000 Aug58(2):658-73.  

Molecular Formula C9HD17NO2
Molecular Weight 190.34300
Exact Mass 190.23700
PSA 23.47000
LogP 1.28370