Propofol-d17

Names

[ CAS No. ]:
1261393-54-7

[ Name ]:
Propofol-d17

[Synonym ]:
2,6-Bis[(2H7)-2-propanyl](2H3)phenol
Phenol-3,4,5-d3, 2,6-bis[1-(methyl-d3)ethyl-1,2,2,2-d4]-

Biological Activity

[Description]:

Propofol-d17 (2,6-Diisopropylphenol-d17) is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid(A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282(3):1181-6.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
256.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C12HD17O

[ Molecular Weight ]:
195.376

[ Flash Point ]:
107.5±7.2 °C

[ Exact Mass ]:
195.242477

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.513

Related Compounds