Hispidulin
Hispidulin structure
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Common Name | Hispidulin | ||
|---|---|---|---|---|
| CAS Number | 1447-88-7 | Molecular Weight | 300.263 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 601.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 230.1±25.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of HispidulinHispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hispidulin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.71 μM (Pim-1)[1] |
| In Vitro | Hispidulin induces cell death in a dose- and time-dependent manner in HepG2 cells. Hispidulin induces apoptosis through mitochondrial dysfunction, which is characterized by decreased Bcl-2/Bax ratio, disrupted mitochondrial membrane potential and increased release of cytochrome C and activated capase-3[2]. |
| In Vivo | Hispidulin shows significant inhibitory effect on mice tumor size[2]. Hispidulin treatment effectively prevents ovariectomy-induced body weight loss and attenuates ovariectomy-induced bone loss. Hispidulin treatment also decreases trabecular spacing in ovariectomy mice[3]. Intraperitoneally administering hispidulin(10 or 50mg/ kg) to rats 30 min before intraperitoneally injecting kainic acid (15mg/kg) increases seizure latency and decreases seizure score. In addition, hispidulin substantially attenuates kainic acid-induced hippocampal neuronal cell death, and this protective effect is accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus[4]. |
| Cell Assay | HepG2 cells are treated with different concentrations of hispidulin (50, 100, 200 μM) for 24, 48 and 72 h. Following treatment, cells are further incubated with MTT reagents at 37°C for 4 h before DMSO is added, to dissolve farmazan crystals, and absorbance is measured at 570 nm in a microplate reader[2]. |
| Animal Admin | Mice: Tumor are established in mice. Mice are treated with DMSO or Hispidulin at a dosage of 10, 20 or 40 mg/kg/day for 35 days. The body weight of tumour-bearing mice is recorded every week and tumour volume is calculated [2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.5±55.0 °C at 760 mmHg |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.263 |
| Flash Point | 230.1±25.0 °C |
| Exact Mass | 300.063385 |
| PSA | 100.13000 |
| LogP | 1.60 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.697 |
| InChIKey | IHFBPDAQLQOCBX-UHFFFAOYSA-N |
| SMILES | COc1c(O)cc2oc(-c3ccc(O)cc3)cc(=O)c2c1O |
| Storage condition | Desiccate at -20°C |
| Water Solubility | DMSO: soluble20mg/mL, clear |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 2 | |
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CAS#:529-53-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control.
J. Agric. Food Chem. 47(11) , 4579-82, (1999) A reversed-phase HPLC procedure is proposed for the determination of seven flavonoids (luteolin, nepetin, hispidulin, jaceosidin, cirsimaritin, cirsilineol, and eupatorin) in vervain samples. A simple... |
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Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein.
Zhongguo Yao Li Xue Bao 15(5) , 385-8, (1994) Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the bin... |
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Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography.
J. Pharm. Biomed. Anal. 48(1) , 100-4, (2008) To control the quality of Salvia plebeia R.Br., a simple and reliable method of high-performance liquid chromatography coupled with photodiode array detector (HPLC-DAD) was developed both for fingerpr... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Binding affinity towards benzodiazepine site in GABAA receptor
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit theta
External Id: CHEMBL877825
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity
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Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Dinatin |
| Scutellarein 6-methyl ether |
| 6-O-Methylapigenin |
| TCMDC-123942 |
| 4',5,7-Trihydroxy-6-methoxyflavone |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one |
| Hispidulin |
| 6-O-Methoxyapigenin |
| 5,7,4'-trihydroxy-6-methoxyflavone |
| 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the physical appearance of hispidulin? |
| A: hispidulin appears as white to beige. |
| Q: What English synonyms does hispidulin have? |
| A: English synonyms of hispidulin: Dinatin, Scutellarein 6-methyl ether, 6-O-Methylapigenin, TCMDC-123942, 4',5,7-Trihydroxy-6-methoxyflavone, 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one, Hispidulin, 6-O-Methoxyapigenin, 5,7,4'-trihydroxy-6-methoxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one. |
| Q: What is the LogP of hispidulin? |
| A: LogP of hispidulin is 1.60. |
| Q: What is the molecular formula of hispidulin? |
| A: Molecular formula of hispidulin is C16H12O6. |
| Q: What is the English name of hispidulin? |
| A: The English name of hispidulin is hispidulin. |
| Q: What is the boiling point of hispidulin? |
| A: Boiling point of hispidulin is 601.5±55.0 °C at 760 mmHg. |
| Q: What is the molecular weight of hispidulin? |
| A: Molecular weight of hispidulin is 300.263. |
| Q: What is the SMILES notation of hispidulin? |
| A: SMILES notation of hispidulin is COc1c(O)cc2oc(-c3ccc(O)cc3)cc(=O)c2c1O. |
| Q: What is the polar surface area (PSA) of hispidulin? |
| A: Polar surface area (PSA) of hispidulin is 100.13000. |
| Q: What is the CAS number of hispidulin? |
| A: CAS number of hispidulin is 1447-88-7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |