Varenicline Tartrate
Varenicline Tartrate structure
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Common Name | Varenicline Tartrate | ||
|---|---|---|---|---|
| CAS Number | 375815-87-5 | Molecular Weight | 361.35 | |
| Density | N/A | Boiling Point | 400.6ºC at 760 mmHg | |
| Molecular Formula | C17H19N3O6 | Melting Point | 206-208ºC | |
| MSDS | Chinese USA | Flash Point | 48.2 °F | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Varenicline TartrateVarenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: α4β2 nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | varenicline tartrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: α4β2 nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking. |
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| Related Catalog | |
| References |
[5]. Varenicline |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 400.6ºC at 760 mmHg |
|---|---|
| Melting Point | 206-208ºC |
| Molecular Formula | C17H19N3O6 |
| Molecular Weight | 361.35 |
| PSA | 23.79000 |
| LogP | 4.49528 |
| InChIKey | TWYFGYXQSYOKLK-UFIFRZAQSA-N |
| SMILES | O=C(O)C(O)C(O)C(=O)O.c1cnc2cc3c(cc2n1)C1CNCC3C1 |
| Storage condition | Desiccate at RT |
| Water Solubility | DMSO: >5mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | Xn,N,T,F |
| Risk Phrases | 22-50-39/23/24/25-23/24/25-11 |
| Safety Phrases | 22-57-45-36/37-16-7 |
| RIDADR | UN 3077 9 / PGIII |
| Flash Point(F) | 48.2 °F |
| Flash Point(C) | 9 °C |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~64%
Varenicline Tartrate CAS#:375815-87-5 |
| Literature: Medichem, S.A. Patent: US2012/4239 A1, 2012 ; Location in patent: Page/Page column 12 ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
|---|---|
| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Concurrent access to nicotine and sucrose in rats.
Psychopharmacol. Ser. 232(8) , 1451-60, (2015) Animal models that allow concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use.We sought to develop and utilize a concurren... |
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Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.
Neuropharmacology 99 , 142-55, (2015) Chronic treatment with nicotine is known to increase the α4β2-nAChR sites in brain, to decrease α6β2-nAChR sites and to have minimal effect on α3β4-and α7-nAChR populations. Varenicline is now used as... |
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Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization.
Alcohol. Clin. Exp. Res. 38(12) , 3033-42, (2015) Varenicline, a partial nicotinic acetylcholine receptor (nAChR) agonist, is a promising new drug for the treatment of alcohol (ethanol [EtOH]) dependence. Varenicline has been approved by the Food and... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine tartrate Champix |
| (2R,3R)-3-carboxy-2,3-dihydroxypropanoate de (1R,12S)-5,8-diaza-14-azoniatétracyclo[10.3.1.0.0]hexadéca-2(11),3,5,7,9-pentaène |
| Chantix |
| (1R,12S)-5,8-Diaza-14-azoniatetracyclo[10.3.1.0.0]hexadeca-2(11),3,5,7,9-pentaene (2R,3R)-3-carboxy-2,3-dihydroxypropanoate |
| (1R,12S)-5,8-Diaza-14-azoniatetracyclo[10.3.1.0.0]hexadeca-2(11),3,5,7,9-pentaen-(2R,3R)-3-carboxy-2,3-dihydroxypropanoat |
| Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (6R,10S)-7,8,9,10-tetrahydro-6,10-methano-6H-azepino[4,5-g]quinoxaline (1:1) |
| Champix |
| Varenicline tartrate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of varenicline tartrate? |
| A: Molecular weight of varenicline tartrate is 361.35. |
| Q: What is the melting point of varenicline tartrate? |
| A: Melting point of varenicline tartrate is 206-208ºC. |
| Q: How is the water solubility of varenicline tartrate? |
| A: Water solubility of varenicline tartrate: DMSO: >5mg/mL. |
| Q: What is the molecular formula of varenicline tartrate? |
| A: Molecular formula of varenicline tartrate is C17H19N3O6. |
| Q: What is the safety information for varenicline tartrate? |
| A: Safety information for varenicline tartrate: 22-57-45-36/37-16-7. |
| Q: What is the English name of varenicline tartrate? |
| A: The English name of varenicline tartrate is varenicline tartrate. |
| Q: What is the InChIKey of varenicline tartrate? |
| A: InChIKey of varenicline tartrate is TWYFGYXQSYOKLK-UFIFRZAQSA-N. |
| Q: What are the storage conditions for varenicline tartrate? |
| A: Storage conditions for varenicline tartrate: Desiccate at RT. |
| Q: What is the LogP of varenicline tartrate? |
| A: LogP of varenicline tartrate is 4.49528. |
| Q: What is the polar surface area (PSA) of varenicline tartrate? |
| A: Polar surface area (PSA) of varenicline tartrate is 23.79000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |