Varenicline

Modify Date: 2025-08-20 18:40:01

Varenicline structure	Common Name	Varenicline
	CAS Number	249296-44-4	Molecular Weight	211.26
	Density	1.247g/cm3	Boiling Point	400.6ºC at 760mmHg
	Molecular Formula	C₁₃H₁₃N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	196.1ºC

Use of Varenicline

Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking.

Name	varenicline
Synonym	More Synonyms

Description	Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.IC50 value:Target: nAChRVarenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers. Journal of Clinical Pharmacology (2011), 51(4), 527-537. [2]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34. [3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125. [4]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

References

[1]. Kikkawa, H.; Maruyama, N.; Fujimoto, Y.; Hasunuma, T. Single- and multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy Japanese adult smokers. Journal of Clinical Pharmacology (2011), 51(4), 527-537.

[2]. Bordia T, Hrachova M, Chin M et al. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum. J Pharmacol Exp Ther. 2012 Aug;342(2):327-34.

[3]. Pachas GN, Cather C, Pratt SA et al. Varenicline for Smoking Cessation in Schizophrenia: Safety and Effectiveness in a 12-Week, Open-Label Trial. J Dual Diagn. 2012;8(2):117-125.

[4]. Krebs P, Sherman SE. Review: Varenicline for tobacco cessation does not increase CV serious adverse events. Ann Intern Med. 2012 Aug 21;157(4):JC2-2.

Density	1.247g/cm3
Boiling Point	400.6ºC at 760mmHg
Molecular Formula	C₁₃H₁₃N₃
Molecular Weight	211.26
Flash Point	196.1ºC
PSA	152.87000
LogP	0.01010
Vapour Pressure	1.25E-06mmHg at 25°C
Index of Refraction	1.667
Storage condition	2-8℃

5,8,14-triazate...

CAS#:1333145-92-8

~83%

Varenicline

CAS#:249296-44-4

Literature: Teva Pharmaceutical Industries Ltd. Patent: US2010/324055 A1, 2010 ; Location in patent: Page/Page column 4-5 ;

5,8,14-triazate...

CAS#:1333146-06-7

~68%

Varenicline

CAS#:249296-44-4

Literature: Teva Pharmaceutical Industries Ltd. Patent: US2010/324055 A1, 2010 ; Location in patent: Page/Page column 5 ;

5,8,14-triazate...

CAS#:1186072-37-6

~61%

Varenicline

CAS#:249296-44-4

Literature: Teva Pharmaceutical Industries Ltd. Patent: US2010/324055 A1, 2010 ; Location in patent: Page/Page column 5 ;

5,8,14-triazate...

CAS#:1197286-22-8

~96%

Varenicline

CAS#:249296-44-4

Literature: TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2009/143347 A2, 2009 ; Location in patent: Page/Page column 25 ;

8-(4-methoxyben...

CAS#:1206484-38-9

~65%

Varenicline

CAS#:249296-44-4

Literature: Pasikanti, Srinivas; Srinivasa Reddy; Venkatesham; Dubey; Iqbal, Javed; Das, Parthasarathi Tetrahedron Letters, 2010 , vol. 51, # 1 p. 151 - 152

Precursor 1
CAS#:1206484-38-9 8-(4-methoxyben...
DownStream 1
CAS#:375815-87-5 Varenicline Tartrate

Vareniclene

Chantix

10-tetrahydro

10-Methano-6H-pyrazino[2

5,8,14-triazatetracycIo[10.3.1.0(2,11).0(4,9)]hexadeca-2(11),3,5,7,9-pentaene

5,8,14-triazatetracyclo[10.3.1.0(2,11),0(4,9)]hexadeca-2(l11),3,5,7,9-pentaene

3-h][3]benzazepine

5,8,14-triazatetracyclo[10.3.1.0(2,11).0(4,9)]hexadeca-2(11),3,5,7,9-pentaene

Varenicline

7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine

Unii-W6hs99o8zo

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Varenicline
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Varenicline
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Varenicline
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Varenicline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Varenicline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

Varenicline suppliers

Price: $84/5mg

Reference only. check more Varenicline price

Varenicline

Use of Varenicline

Names

Varenicline Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.