(+)-Bicuculline
(+)-Bicuculline structure
|
Common Name | (+)-Bicuculline | ||
|---|---|---|---|---|
| CAS Number | 485-49-4 | Molecular Weight | 367.352 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 542.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H17NO6 | Melting Point | 196-198 ºC | |
| MSDS | Chinese USA | Flash Point | 281.8±30.1 °C | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
Use of (+)-Bicuculline(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | bicuculline |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. |
|---|---|
| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 542.3±50.0 °C at 760 mmHg |
| Melting Point | 196-198 ºC |
| Molecular Formula | C20H17NO6 |
| Molecular Weight | 367.352 |
| Flash Point | 281.8±30.1 °C |
| Exact Mass | 367.105591 |
| PSA | 66.46000 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.665 |
| InChIKey | IYGYMKDQCDOMRE-ZWKOTPCHSA-N |
| SMILES | CN1CCc2cc3c(cc2C1C1OC(=O)c2c1ccc1c2OCO1)OCO3 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H311 + H331-H400 |
| Precautionary Statements | P261-P264-P273-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic;N: Dangerous for the environment; |
| Risk Phrases | R23/24/25 |
| Safety Phrases | S36/37-S45-S61 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | LV0909840 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
![Furo[3,4-e]-1,3-benzodioxole-6-carboxylicacid, 6,8-dihydro-8-oxo structure](https://image.chemsrc.com/caspic/411/64395-07-9.png)
![N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-8-oxo-6,8-dihydro-[1,3]dioxolo[4,5-e]isobenzofuran-6-carboxamide structure](https://image.chemsrc.com/caspic/381/185022-35-9.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 1 | |
CAS#:40709-69-1This table lists relevant public references with title, journal and publication metadata for this compound.
|
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Nat. Commun. 6 , 6872, (2015) Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addit... |
|
|
Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.
Cell Death Differ. 22 , 1425-36, (2015) Impairment of synaptic function can lead to neuropsychiatric disorders collectively referred to as synaptopathies. The SNARE protein SNAP-25 is implicated in several brain pathologies and, indeed, bra... |
|
|
Forebrain NR2B overexpression enhancing fear acquisition and long-term potentiation in the lateral amygdala.
Eur. J. Neurosci. 42 , 2214-23, (2015) N-methyl-d-aspartic acid (NMDA) receptor-dependent long-term potentiation (LTP) at the thalamus-lateral amygdala (T-LA) synapses is the basis for acquisition of auditory fear memory. However, the role... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: In vitro displacement of [3H]muscimol from Gamma-aminobutyric acid A receptor of rat ...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-3
External Id: CHEMBL681563
|
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
|
|
Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
|
|
Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
|
|
Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| D-BICUCULLINE |
| EINECS 207-619-7 |
| BICUCULLINE (+) |
| (+)-Bicuculline |
| PLUS-BICUCULLINE |
| bicucculine |
| (6R)-6-[(5S)-6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one |
| MFCD00005006 |
| Bicuculline |
| bicucullin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of bicuculline? |
| A: Boiling point of bicuculline is 542.3±50.0 °C at 760 mmHg. |
| Q: What is the safety information for bicuculline? |
| A: Safety information for bicuculline: S36/37-S45-S61. |
| Q: What English synonyms does bicuculline have? |
| A: English synonyms of bicuculline: D-BICUCULLINE, EINECS 207-619-7, BICUCULLINE (+), (+)-Bicuculline, PLUS-BICUCULLINE, bicucculine, (6R)-6-[(5S)-6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one, MFCD00005006, Bicuculline, bicucullin. |
| Q: What is the CAS number of bicuculline? |
| A: CAS number of bicuculline is 485-49-4. |
| Q: What is the molecular weight of bicuculline? |
| A: Molecular weight of bicuculline is 367.352. |
| Q: What are the uses of bicuculline? |
| A: Main uses of bicuculline: (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. |
| Q: What is the SMILES notation of bicuculline? |
| A: SMILES notation of bicuculline is CN1CCc2cc3c(cc2C1C1OC(=O)c2c1ccc1c2OCO1)OCO3. |
| Q: What is the InChIKey of bicuculline? |
| A: InChIKey of bicuculline is IYGYMKDQCDOMRE-ZWKOTPCHSA-N. |
| Q: What is the LogP of bicuculline? |
| A: LogP of bicuculline is 2.88. |
| Q: What are the upstream materials of bicuculline? |
| A: Related upstream materials(CAS) of bicuculline: 50-00-0;56083-00-2;64395-07-9;58343-48-9;185022-35-9. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |