SBI-553

Modify Date: 2025-08-25 18:46:51

SBI-553 structure	Common Name	SBI-553
	CAS Number	1849603-72-0	Molecular Weight	450.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₁FN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SBI-553

SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1].

Name	SBI-553

Description	SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Others
Target	EC50: 0.34 μM (NTR1)[1].
References	[1]. Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.

Molecular Formula	C₂₆H₃₁FN₄O₂
Molecular Weight	450.55
Storage condition	-20°C

Name: Binding affinity to alpha2A adrenoceptor (unknown origin) at 5 uM relative to control
Source: ChEMBL
Target: Alpha-2A adrenergic receptor
External Id: CHEMBL4375493

Name: NTR1 Ca2+ Flux Dose Response from US Patent US10584103: "Small molecule agonists of n...
Source: BindingDB
Target: N/A
External Id: BindingDB_8995_1

Name: Binding affinity to D1R (unknown origin) at 5 uM relative to control
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL4375494

Name: Binding affinity to H1R (unknown origin) at 5 uM relative to control
Source: ChEMBL
Target: Histamine H1 receptor
External Id: CHEMBL4375495

Name: Binding affinity to 5HT2B (unknown origin) at 5 uM relative to control
Source: ChEMBL
Target: 5-hydroxytryptamine receptor 2B
External Id: CHEMBL4375496

Name: Allosteric modulation of human PK-tagged Gi/Go-coupled KOR expressed in CHOK1 cells a...
Source: ChEMBL
Target: Kappa-type opioid receptor
External Id: CHEMBL4375484

Name: Toxicity in DAT knockout C57BL/6J mouse assessed as hypotension at 12 mg/kg, ip
Source: ChEMBL
Target: N/A
External Id: CHEMBL4375487

Name: NTR1 Ca2+ Flux Dose Response from US Patent US10118902: "Small molecule agonists of n...
Source: BindingDB
Target: N/A
External Id: BindingDB_903_1

Name: Toxicity in DAT knockout C57BL/6J mouse assessed as hypothermia at 12 mg/kg, ip
Source: ChEMBL
Target: N/A
External Id: CHEMBL4375488

Name: Suppression of hyperlocomotion in DAT knockout C57BL/6J mouse assessed as reduction i...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL4375491

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SBI-553

Use of SBI-553

Names

SBI-553 Biological Activity

Chemical & Physical Properties

SBI-553Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.