1451272-71-1

1451272-71-1 structure

Name: SBI-425
Chemical Name: SBI-425
CAS Number: 1451272-71-1
Molecular Formula: C₁₃H₁₂ClN₃O₄S
Molecular Weight: 341.77
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2019-10-07 19:59:13
Modify Date: 2025-09-19 10:45:05
SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].

Name	SBI-425
Synonyms	MFCD31652984

Description	SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor[1]. Long-term administration of SBI-425 effectively reaches and inhibits TNAP in the vasculature, improving cardiovascular parameters and survival at a dose that does not cause a detectable change in bone[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
References	[1]. Pinkerton AB, et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34. [2]. Sheen CR, et al. Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36.