701232-94-2
701232-94-2 structure
- Name: JTT-553
- Chemical Name: JTT-553
- CAS Number: 701232-94-2
- Molecular Formula: C25H27F3N4O3
- Molecular Weight: 488.511
- Create Date: 2020-01-20 17:31:56
- Modify Date: 2024-04-06 06:40:18
-
JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats. Obesity Phase 1 Discontinued
| Name | JTT-553 |
|---|
| Description | JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats. Obesity Phase 1 Discontinued |
|---|---|
| References | References 1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9. 2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8. View Related Products by Target Diglyceride Acyltransferase (DGAT) Obesity |
| Molecular Formula | C25H27F3N4O3 |
|---|---|
| Molecular Weight | 488.511 |