JTT-553
Modify Date: 2024-04-06 06:40:18
JTT-553 structure
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Common Name | JTT-553 | ||
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| CAS Number | 701232-94-2 | Molecular Weight | 488.511 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H27F3N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JTT-553JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats. Obesity Phase 1 Discontinued |
| Name | JTT-553 |
|---|
| Description | JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats. Obesity Phase 1 Discontinued |
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| References | References 1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9. 2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8. View Related Products by Target Diglyceride Acyltransferase (DGAT) Obesity |
| Molecular Formula | C25H27F3N4O3 |
|---|---|
| Molecular Weight | 488.511 |