JTT-553
Names
[ CAS No. ]:
701232-94-2
[ Name ]:
JTT-553
Biological Activity
[Description]:
JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM); suppresses plasma TG and chylomicron TG levels after olive oil loading in Sprague-Dawley (SD) rats; also reduces daily food intake and body weight gain in diet-induced obesity rats. Obesity Phase 1 Discontinued
[References]
References 1. Tomimoto D, et al. Biol Pharm Bull. 2015;38(2):263-9. 2. Tomimoto D, et al. J Pharmacol Sci. 2015 Sep;129(1):51-8. View Related Products by Target Diglyceride Acyltransferase (DGAT) Obesity
Chemical & Physical Properties
[ Molecular Formula ]:
C25H27F3N4O3
[ Molecular Weight ]:
488.511