e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

The effects of substituting tetrazole for carboxyl in two series of anti??inflammatory phenoxyacetic acids

…, M Horlington, JGB Howes, JM Scruton…

Index: Drain; Daly; Davy; Horlington; Howes; Scruton; Selway The Journal of pharmacy and pharmacology, 1970 , vol. 22, # 9 p. 684 - 693

Full Text: HTML

Citation Number: 12

Abstract

Series of o-phenylcarbamoyl-and o-benzamido-phenoxymethyl tetrazoles and o- phenylcarbamoylphenoxyacetic acids have been synthesized. Anti-inflammatory activity was measured by the phenyl benzoquinone writhing test in mice and the rat foot carrageenan oedema test. Potency in the two o-benzamido substituted series could not be related with structure in a satisfactory manner. Introduction of substituents into the benzene rings of the ...

aminophenol Structure

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

3,4-dichloro-N-(2-hydroxyphenyl)benzamide Structure

3,4-dichloro-N-...

(2R)-2-Chloropropanoyl chloride Structure

(2R)-2-Chloropr...

2-Amino-4-methylphenol Structure

2-Amino-4-methy...

~%

2-chloro-N-(2-hydroxy-5-methylphenyl)propanamide Structure

2-chloro-N-(2-h...

6-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE Structure

6-METHYL-2H-1,4...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

2-[2-[(3,4-dichlorobenzoyl)amino]-4-methylphenoxy]acetic acid Structure

2-[2-[(3,4-dich...

2-(2-chloro-acetylamino)-4-ethyl-phenol Structure

2-(2-chloro-ace...

~%

benzyl 6-methyl-4-(4-nitrophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxylate Structure

benzyl 6-methyl...

2-amino-4-ethylphenol Structure

2-amino-4-ethyl...

~%

benzyl 6-methyl-4-(4-nitrophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxylate Structure

benzyl 6-methyl...

6-Hydroxy-2H-1,4-benzoxazin-3(4H)-one Structure

6-Hydroxy-2H-1,...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

2-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]benzo[de]isoquinoline-1,3-dione Structure

2-[4-(3,4-dihyd...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

7-Methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one Structure

7-Methoxy-2H-be...

~%

2-[2-[(4-chlorobenzoyl)amino]-5-methoxyphenoxy]acetic acid Structure

2-[2-[(4-chloro...

2-(2-chloro-acetylamino)-3,5-dimethyl-phenol Structure

2-(2-chloro-ace...

~%

2-[2-[4-(furan-2-carbonyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione Structure

2-[2-[4-(furan-...

5,7-dimethyl-4H-benzo[1,4]oxazin-3-one Structure

5,7-dimethyl-4H...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

2-[2-[4-(furan-2-carbonyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione Structure

2-[2-[4-(furan-...

2H-1,4-Benzoxazin-3(4H)-one Structure

2H-1,4-Benzoxaz...

Benzoyl chloride,2-hydroxy- Structure

Benzoyl chlorid...

~%

methyl (Z)-2-hydroxy-4-oxo-4-thiophen-2-ylbut-2-enoate Structure

methyl (Z)-2-hy...

6-chloro-2h-1,4-benzoxazin-3(4h)-one Structure

6-chloro-2h-1,4...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

~%

2-[4-chloro-2-[(4-chlorobenzoyl)amino]phenoxy]acetic acid Structure

2-[4-chloro-2-[...

2H-1,4-Benzoxazin-3(4H)-one Structure

2H-1,4-Benzoxaz...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

Clamidoxic Structure

(2-Nitrophenoxy)acetic acid Structure

(2-Nitrophenoxy...

Benzoyl chloride Structure

Benzoyl chloride

~%

2-(2-benzamidophenoxy)acetic acid Structure

2-(2-benzamidop...

2H-1,4-Benzoxazin-3(4H)-one Structure

2H-1,4-Benzoxaz...

p-toluoyl chloride Structure

p-toluoyl chloride

~%

2-[2-[(4-methylbenzoyl)amino]phenoxy]acetic acid Structure

2-[2-[(4-methyl...

6-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE Structure

6-METHYL-2H-1,4...

3-(Trifluoromethyl)benzoyl chloride Structure

3-(Trifluoromet...

~%

2-[4-methyl-2-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]acetic acid Structure

2-[4-methyl-2-[...

6-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE Structure

6-METHYL-2H-1,4...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

~%

2-[2-[(4-chlorobenzoyl)amino]-4-methylphenoxy]acetic acid Structure

2-[2-[(4-chloro...

6-chloro-2h-1,4-benzoxazin-3(4h)-one Structure

6-chloro-2h-1,4...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

2-[4-chloro-2-[(3,4-dichlorobenzoyl)amino]phenoxy]acetic acid Structure

2-[4-chloro-2-[...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

7-Methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one Structure

7-Methoxy-2H-be...

~%

2-[2-[(3,4-dichlorobenzoyl)amino]-5-methoxyphenoxy]acetic acid Structure

2-[2-[(3,4-dich...

6-Bromo-2H-1,4-benzoxazin-3(4H)-one Structure

6-Bromo-2H-1,4-...

2,3-Dichlorobenzoyl Structure

2,3-Dichlorobenzoyl

~%

methyl 4-[(8-methyl-2-oxo-4-phenylchromen-7-yl)oxymethyl]benzoate Structure

methyl 4-[(8-me...