Solvent??Free Buchwald–Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

…, AF Asachenko, MS Nechaev

Index: Topchiy, Maxim A.; Asachenko, Andrey F.; Nechaev, Mikhail S. European Journal of Organic Chemistry, 2014 , vol. 2014, # 16 p. 3319 - 3322

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Citation Number: 5

Abstract

Abstract A highly efficient solvent-free protocol for the Buchwald–Hartwig amination of (hetero) aryl halides by secondary amines was developed. The reaction is mediated by a Pd (OAc) 2/RuPhos catalytic system in air. Various (hetero) aryl halides were coupled with diaryl, alkyl–aryl, and dialkylamines in good to excellent yields (51 examples, 50–99% yield).

~67%

~96%

~99%

~99%

~97%

~95%

~99%

~87%

~98%

~99%

~10%

~10%

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