Solvent??Free Buchwald–Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

…, AF Asachenko, MS Nechaev

文献索引：Topchiy, Maxim A.; Asachenko, Andrey F.; Nechaev, Mikhail S. European Journal of Organic Chemistry, 2014 , vol. 2014, # 16 p. 3319 - 3322

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被引用次数: 5

摘要

Abstract A highly efficient solvent-free protocol for the Buchwald–Hartwig amination of (hetero) aryl halides by secondary amines was developed. The reaction is mediated by a Pd (OAc) 2/RuPhos catalytic system in air. Various (hetero) aryl halides were coupled with diaryl, alkyl–aryl, and dialkylamines in good to excellent yields (51 examples, 50–99% yield).

~67%

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~96%

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~99%

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~99%

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~97%

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~95%

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~99%

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~87%

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~98%

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~99%

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~10%

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~10%

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