Direct Base??Assisted C–N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition??Metal??Free Conditions

Y Fang, Y Zheng, Z Wang

Index: Fang, Yang; Zheng, Yueqin; Wang, Zhiyong European Journal of Organic Chemistry, 2012 , # 8 p. 1495 - 1498

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Citation Number: 15

Abstract

Abstract Direct base-mediated amination of aryl halides with aliphatic tertiary amines via an aryne intermediate was developed under transition-metal-free conditions. This operationally simple C–N bond-coupling protocol could tolerate a variety of functionalized aryl halides as well as several aliphatic tertiary amines. Moreover, this environmentally benign process provides a new strategy for direct C–N bond formation.

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