Recyclable Heterogeneous Supported Copper??Catalyzed Coupling of Thiols with Aryl Halides: Base??Controlled Differential Arylthiolation of Bromoiodobenzenes

S Bhadra, B Sreedhar, BC Ranu

Index: Bhadra, Sukalyan; Sreedhar, Bojja; Ranu, Brindaban C. Advanced Synthesis and Catalysis, 2009 , vol. 351, # 14-15 p. 2369 - 2378

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Citation Number: 73

Abstract

Abstract Alumina-supported copper sulfate efficiently catalyzes the S-arylation of aromatic, heteroaromatic and aliphatic thiols with aryl as well as heteroaryl halides under aerobic, ligand-free conditions. This protocol provides an easy access to a variety of thioethers as well as unsymmetrical bis-thioethers by base-controlled differential coupling of thiols with iodo-and bromo-substituents in an aromatic halide. The catalyst is inexpensive, non-air ...