2-Chloropyridine

Modify Date: 2024-01-01 21:07:16

2-Chloropyridine Structure
2-Chloropyridine structure
 Common Name 2-Chloropyridine
CAS Number 109-09-1 Molecular Weight 113.545
Density 1.2±0.1 g/cm3 Boiling Point 170.0±0.0 °C at 760 mmHg
Molecular Formula C5H4ClN Melting Point -46 °C
MSDS Chinese USA Flash Point 65.0±0.0 °C
Symbol GHS05 GHS06 GHS08 GHS09
GHS05, GHS06, GHS08, GHS09		 Signal Word Danger

 Names

Name 2-Chloropyridine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 170.0±0.0 °C at 760 mmHg
Melting Point -46 °C
Molecular Formula C5H4ClN
Molecular Weight 113.545
Flash Point 65.0±0.0 °C
Exact Mass 113.003227
PSA 12.89000
LogP 1.40
Vapour Pressure 2.0±0.3 mmHg at 25°C
Index of Refraction 1.530
Water Solubility 27 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US5950000
CHEMICAL NAME :
Pyridine, 2-chloro-
CAS REGISTRY NUMBER :
109-09-1
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C5-H4-Cl-N
MOLECULAR WEIGHT :
113.55
WISWESSER LINE NOTATION :
T6NJ BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 ppm/4H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
48 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Liver - fatty liver degeneration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
1980 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 301,57,1993

 Safety Information

Symbol GHS05 GHS06 GHS08 GHS09
GHS05, GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H302-H310 + H330-H315-H318-H335-H373-H410
Precautionary Statements P260-P280-P302 + P352 + P310-P304 + P340 + P310-P305 + P351 + P338 + P310-P403 + P233
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic
Risk Phrases R23/24/25;R36/37/38
Safety Phrases S26-S36/37/39-S45-S28A
RIDADR UN 2822 6.1/PG 2
WGK Germany 3
RTECS US5950000
Packaging Group II
Hazard Class 6.1
HS Code 2933399090

 Synthetic Route

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles13

More Articles
Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents

Bioorg. Med. Chem. 18 , 7836-41, (2010)

Antiproliferative assay results indicated that compounds 6o and 6u exhibited the most potent activity against gastric cancer cell SGC-7901, which was more potent than the positive control. Especially,...
Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents.

Bioorg. Med. Chem. Lett. 20 , 4163-4167, (2010)

A series of novel 2-chloro-pyridine derivatives containing flavone, chrome or dihydropyrazole moieties as potential telomerase inhibitors were synthesized. The bioassay tests showed that compounds 6e ...
Detailed compositional characterization of plastic waste pyrolysis oil by comprehensive two-dimensional gas-chromatography coupled to multiple detectors.

J. Chromatogr. A. 1359 , 237-46, (2014)

The detailed compositional characterization of plastic waste pyrolysis oil was performed with comprehensive two-dimensional GC (GC×GC) coupled to four different detectors: a flame ionization detector ...

 Synonyms

Pyridine,2-chloro-
α-Chloropyridine
2-Cl-pyridine
2-Chloro-pyridine
o-Chloropyridine
2-Chloropyridine
T6NJ BG
EINECS 203-646-3
MFCD00006228
Pyridine, 2-chloro-
2-pyridinyl chloride
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