4-Chlorotoluene

Modify Date: 2025-08-21 16:21:59

4-Chlorotoluene structure	Common Name	4-Chlorotoluene
	CAS Number	106-43-4	Molecular Weight	126.584
	Density	1.1±0.1 g/cm3	Boiling Point	162 ºC
	Molecular Formula	C₇H₇Cl	Melting Point	6-8 °C(lit.)
	MSDS	Chinese USA	Flash Point	49 ºC
	Symbol	GHS02, GHS07, GHS09	Signal Word	Warning

Name	4-Chlorotoluene
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	162 ºC
Melting Point	6-8 °C(lit.)
Molecular Formula	C₇H₇Cl
Molecular Weight	126.584
Flash Point	49 ºC
Exact Mass	126.023628
LogP	3.27
Vapour density	4.38 (vs air)
Vapour Pressure	3.4±0.3 mmHg at 25°C
Index of Refraction	1.524
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	<0.1 g/100 mL at 20 ºC

4-Chlorotoluene MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XS9010000

CHEMICAL NAME :: Toluene, p-chloro-

CAS REGISTRY NUMBER :: 106-43-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C7-H7-Cl

MOLECULAR WEIGHT :: 126.59

WISWESSER LINE NOTATION :: GR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS0513162

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(12),64,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,38,1982

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,38,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(2),67,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3750 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(2),67,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 mg/kg/26W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - hepatitis (hepatocellular necrosis), zonal Liver - liver function tests impaired

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(2),67,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25200 mg/kg/2W-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(5),487,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 72 gm/kg/90D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 9(5),487,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993

Symbol	GHS02, GHS07, GHS09
Signal Word	Warning
Hazard Statements	H226-H317-H332-H411
Precautionary Statements	P273-P280
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R20;R51/53
Safety Phrases	S24/25-S61-S45-S36/37-S16-S7
RIDADR	UN 2238 3/PG 3
WGK Germany	2
RTECS	XS9010000
Packaging Group	III
Hazard Class	3
HS Code	29337900

Precursor 10
CAS#:106-38-7 4-Bromotoluene CAS#:108-88-3 Toluene CAS#:6258-66-8 4-Chlorobenzyl ... CAS#:624-31-7 4-Iodotoluene
CAS#:104-88-1 4-Chlorobenzaldehyde CAS#:104-83-6 4-Chlorobenzyl ... CAS#:622-95-7 4-Chlorobenzyl ... CAS#:873-76-7 p-chlorobenzyla...
CAS#:23229-32-5 4-Chlorobenzald... CAS#:106-49-0 p-Toluidine
DownStream 10
CAS#:107271-15-8 2-(4-methylphen... CAS#:5216-25-1 p-Chlorobenzotr... CAS#:352-32-9 4-Fluorotoluene CAS#:95-52-3 2-Fluorotoluene
CAS#:352-70-5 3-Fluorotoluene CAS#:34981-38-9 5-Chloro-2-meth... CAS#:50670-50-3 4'-Methyl-4-bip... CAS#:3333-13-9 1-allyl-4-methy...
CAS#:104-93-8 4-Methylanisole CAS#:108-88-3 Toluene

HS Code	2903991000
Summary	2903991000 1-chloro-4-methylbenzene。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

Optimizations of packed sorbent and inlet temperature for large volume-direct aqueous injection-gas chromatography to determine high boiling volatile organic compounds in water.

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For the expanded application area, fast trace analysis of certain high boiling point (i.e., 150-250 °C) volatile organic compounds (HVOCs) in water, a large volume-direct aqueous injection-gas chromat...

Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases.

ACS Chem. Biol. 10 , 2501-11, (2015)

Terpenes are ubiquitous natural chemicals with diverse biological functions spanning all three domains of life. In specialized metabolism, the active sites of terpene synthases (TPSs) evolve in shape ...

P-CHLOROTOLUENE

4-methyl-chlorobenzene

1-chloro-4-methylbenzeene

4-Chlorotoluene

EINECS 203-397-0

1-Chloro-4-methyl-benzene

4-chloro-1-methyl-anthraquinone

1-chloro-4-methyl-9,10-dihydro-9,10-anthracenedione

4-Methylchlorobenzene

1-Methyl-4-chlor-anthrachinon

1-chloro-4-methyl-9,10-anthraquinone

4-Chlor-1-methyl-anthrachinon

P-TOLYL CHLORIDE

9,1-chloro-4-methyl

para-chlorotoluene

toluene, 4-chloro-

9,10-Anthracenedione,1-chloro-4-methyl

1-Chloro-4-methylbenzene

Benzene, 1-chloro-4-methyl-

1-chloro-4-methylanthraquinone

4-tolyl chloride

MFCD00000631

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Chlorotoluene
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Chlorotoluene
Price: ￥138.0/500ml
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Chlorotoluene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Chlorotoluene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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4-Chlorotoluene

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