(3β,7α)-Cholest-5-ene-3,7,25-triol
(3β,7α)-Cholest-5-ene-3,7,25-triol structure
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Common Name | (3β,7α)-Cholest-5-ene-3,7,25-triol | ||
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| CAS Number | 64907-22-8 | Molecular Weight | 418.652 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 548.5±35.0 °C at 760 mmHg | |
| Molecular Formula | C27H46O3 | Melting Point | 235 - 236 °C | |
| MSDS | Chinese USA | Flash Point | 230.5±20.5 °C | |
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Detection of dihydroxycholesterols in human plasma using HPLC-ESI-MS/MS.
Steroids 99 , 131-8, (2015) We report a straightforward sample preparation procedure and a direct liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method for the analysis of 7alpha,25-dihydroxycholesterol (7α25-OHC) and 7alpha,27-dihydroxycholesterol... |
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Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase.
Biochim. Biophys. Acta 1344(3) , 241-9, (1997) The metabolism of 25-hydroxycholesterol in different cell types was studied and the role of 7 alpha-hydroxylation for the effect of 25-hydroxycholesterol on the activity of HMG-CoA reductase was determined. Human diploid fibroblasts (HDF) and the human melano... |
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Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).
J. Biol. Chem. 287(42) , 35470-83, (2012) Oxysterols are oxygenated cholesterol derivates that are emerging as a physiologically important group of molecules. Although they regulate a range of cellular processes, only few oxysterol-binding effector proteins have been identified, and the knowledge of ... |
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Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.
Immunity 37(3) , 535-48, (2012) 7α,25-dihydroxycholesterol (7α,25-OHC) is a ligand for the G protein-coupled receptor EBI2; however, the cellular sources of this oxysterol are undefined. 7α,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and ... |
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Studies on the immunosuppressive properties of 7,25-dihydroxycholesterol--I. Reduction of interleukin production by treated lymphocytes.
Int. J. Immunopharmacol. 10(5) , 511-8, (1988) Several oxysterols are powerful immunosuppressors. Among them 7,25-dihydroxycholesterol (7,25-OHC) seems to be particularly interesting. The effect of this synthetic sterol on murine lymphocytes, stimulated by Con A, or by allogeneic or TNP-modified syngeneic... |
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Oxysterols, but not cholesterol, inhibit human immunodeficiency virus replication in vitro.
Antivir. Chem. Chemother. 9(6) , 491-6, (1998) Oxysterols, oxygenated derivatives of cholesterol selected for their cytostatic activity and their inhibitory effect on cholesterol synthesis, have been investigated for their anti-human immunodeficiency virus (HIV) activity in vitro. The three oxysterols tes... |
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Studies on the immunosuppressive properties of 7,25 dihydroxycholesterol--II. Effects on early steps of T-cell activation.
Int. J. Immunopharmacol. 11(5) , 559-65, (1989) The effects of an oxysterol, 7,25-dihydroxycholesterol (7,25-OHC), cyclosporin A (CsA) and dexamethasone (Dex) on the blastogenic response of murine lymphocytes to various stimuli were investigated. 7,25-OHC markedly depressed the response to Con A, anti-T3 m... |
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Oxysterols: functional significance in fetal development and the maintenance of normal retinal function.
Curr. Opin. Lipidol. 18(3) , 283-8, (2007) Recent findings extend the biologic activities of oxysterols as ligands for nuclear receptors to a role in morphogenesis during fetal development and to a role in the metabolism of photooxidation products of cholesterol in the retina.A 1000-fold increase of t... |
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Antiproliferative effects of two hydrosoluble derivatives of oxysterols on cultured lymphoma cells.
Cancer Biochem. Biophys. 11(1) , 45-57, (1990) The antitumor effects of two new hydrosoluble derivatives of oxygenated sterols: JB69 and JC40 have been evaluated in vitro on a panel of lymphoma and leukemia cells from human and murine origins. These compounds result from the combination of a nucleotide wi... |
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Studies on the immunological properties of oxysterols: in vivo actions of 7,25-dihydroxycholesterol upon murine peritoneal cells.
Immunology 70(3) , 344-50, (1990) Oxygenated derivatives of cholesterol are potent immunosuppressors. It has been reported previously that 7,25-dihydroxycholesterol (7,25-OHC), synthesized in the URA31, strongly inhibits the early steps of T-cell activation. So far, the mechanisms underlying ... |