Tetramethylpyrazine
Tetramethylpyrazine structure
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Common Name | Tetramethylpyrazine | ||
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| CAS Number | 1124-11-4 | Molecular Weight | 136.19 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 192.7±35.0 °C at 760 mmHg | |
| Molecular Formula | C8H12N2 | Melting Point | 77-80 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 71.6±17.6 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Characterization of Volatile Flavor Compounds in Chinese Rice Wine Fermented from Enzymatic Extruded Rice.
J. Food Sci. 80 , C1476-89, (2015) Enzymatic extrusion, instead of traditional steam cooking, to treat rice is an efficient and alternative pretreatment for Chinese rice wine fermentation. In order to determine the formation of volatiles in enzymatic extrusion-processed rice wine (EE), and to ... |
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Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
Pharmazie 69(7) , 532-6, (2014) The pregnane X receptor (PXR) is a key regulator of CYP3A4, which is involved in catalyzing the metabolic conversion of a number of endogenous substrates. In this study, we screened 22 compounds isolated from traditional Chinese herbal medicines using lucifer... |
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Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
Bioorg. Med. Chem. 16 , 8868-74, (2008) Ischemic stroke results from brain blood vessel blockage by thrombus, and produces neuronal cell damage and death. While thrombolytic therapy with tPA has achieved some success in clinic, the strategy of using neuroprotective agents to treat ischemic stroke h... |
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Effect of Xiongbing compound on the pharmacokinetics and brain targeting of tetramethylpyrazine.
J. Pharm. Pharmacol. 64(11) , 1688-94, (2012) To investigate the effect of the Xiongbing compound (XBC) on the pharmacokinetics and brain targeting of tetramethylpyrazine (TMP).Three microemulsions containing the same TMP concentration were prepared. XBC microemulsions were made from Rhizoma ligustric Ch... |
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Preparation of natural borneol/2-hydroxypropyl-β-cyclodextrin inclusion complex and its effect on the absorption of tetramethylpyrazine phosphate in mouse.
Chem. Pharm. Bull. 60(6) , 736-42, (2012) Natural borneol (NB)/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex has been prepared, and characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and Fourier transform infrared spectroscopy (FT-IR). The phase solubili... |
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Antiviral effects of the constituents derived from Chinese herb medicines on infectious bursal disease virus.
Pharm. Biol. 51(9) , 1137-43, (2013) The prevalence of infectious bursal disease has brought about enormous financial losses to the world poultry industry. Chinese herb medicines can provide valuable materials for discovery and development of new drugs.To screen constituents derived from Chinese... |
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Ligustrazine derivatives. Part 6: design, synthesis and evaluation of novel ligustrazinyl acylguanidine derivatives as potential cardiovascular agents.
Med. Chem. 8(5) , 928-33, (2012) A series of novel Ligustrazinyl acylguanidines was designed, synthesized and evaluated for their protective effect on injured vascular endothelial cell (ECV-304). The preliminary results demonstrated that some compounds possessed more potent activities than t... |
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Protective action of tetramethylpyrazine on the medulla oblongata in rats with chronic hypoxia.
Auton. Neurosci. 173(1-2) , 45-52, (2013) Tetramethylpyrazine (TMP), one of the active ingredients of the Chinese herb Lingusticum Wallichii Frantchat (Chuan Xiong), plays an important role in neuroprotection. However, the protective effect of TMP on the medulla oblongata, the most important region o... |
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Ligustrazine and the contractile properties of soleus muscle in hindlimb-unloaded rats.
Aviat. Space. Environ. Med. 83(11) , 1049-54, (2012) In this study we investigated the effects of different dosages of ligustrazine (tetramethylpyrazine, Tmp) on soleus function and sarco(endo)plasmatic reticulum Ca(2+)-ATPase (SERCA) activity in 14-d hindlimb-unloaded (HU) rats.Female Sprague-Dawley rats were ... |
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Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the phosphatidylinositol 3-kinase/Akt pathway.
Ann. Clin. Lab. Sci. 42(2) , 198-202, (2012)
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