Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Tetramethylpyrazine
Price: ￥228.0/20mg ￥128.0/25g ￥358.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Tetramethylpyrazine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tetramethylpyrazine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2,3,5,6-Tetramethyl pyrazine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Tetramethylpyrazine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

1124-11-4

1124-11-4 structure

Name: Tetramethylpyrazine
Chemical Name: Tetramethylpyrazine
CAS Number: 1124-11-4
Molecular Formula: C₈H₁₂N₂
Molecular Weight: 136.19
Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
Create Date: 2018-07-16 20:23:13
Modify Date: 2024-01-02 22:30:26
Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].

Name	Tetramethylpyrazine
Synonyms	Pyrazine, 2,3,5,6-tetramethyl- MFCD00006146 Chuanxingzine Ligustrazine 2,3,5,6-Tetramethylpyrazine EINECS 214-391-2 2,3,5,6,-Tetramethyl-1,4-pyrazine PPyrazine, tetramethyl- Tetramethyl-1,4-diazine Tetramethylpyrazine 2,3,5,6-TETRA METHYL PYRAZINE

Description	Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vitro	Tetramethylpyrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Tetramethylpyrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury[1].
References	[1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638. [2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6. [3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201.

Density	1.0±0.1 g/cm3
Boiling Point	192.7±35.0 °C at 760 mmHg
Melting Point	77-80 °C(lit.)
Molecular Formula	C₈H₁₂N₂
Molecular Weight	136.19
Flash Point	71.6±17.6 °C
Exact Mass	136.100052
PSA	25.78000
LogP	1.56
Vapour Pressure	0.7±0.4 mmHg at 25°C
Index of Refraction	1.504
Stability	Stable. Incompatible with strong acids, strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ3905000

CHEMICAL NAME :: Pyrazine, tetramethyl-

CAS REGISTRY NUMBER :: 1124-11-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H12-N2

MOLECULAR WEIGHT :: 136.22

WISWESSER LINE NOTATION :: T6N DNJ B1 C1 E1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1910 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,249,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJCREE International Journal of Crude Drug Research. (Swets & Zeitlinger B.V., POB 825, 2160 SZ Lisse, Netherlands) V.20- 1982- Volume(issue)/page/year: 23,119,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 239 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 4,319,1978

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UQ3905000
HS Code	29339990

Precursor 8
513-86-0 17117-97-4 27023-19-4 75-24-1
513-85-9 6628-81-5 56-84-8 108-24-7
DownStream 9
107209-24-5 22978-83-2 22978-84-3 186534-01-0
184826-44-6 75907-74-3 186534-02-1 892396-47-3
79074-45-6

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1124-11-4	22978-84-3
22978-83-2	76494-51-4
105256-26-6	848645-86-3
76556-07-5	57383-80-9
126400-81-5	863870-80-8