L-thyroxine
L-thyroxine structure
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Common Name | L-thyroxine | ||
|---|---|---|---|---|
| CAS Number | 51-48-9 | Molecular Weight | 776.870 | |
| Density | 2.6±0.1 g/cm3 | Boiling Point | 576.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H11I4NO4 | Melting Point | 235 °C | |
| MSDS | Chinese USA | Flash Point | 302.3±30.1 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Inducible, tightly regulated and growth condition-independent transcription factor in Saccharomyces cerevisiae.
Nucleic Acids Res. 42(17) , e130, (2014) The precise control of gene expression is essential in basic biological research as well as in biotechnological applications. Most regulated systems available in yeast enable only the overexpression of the target gene, excluding the possibility of intermediat... |
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Replisome-mediated translesion synthesis and leading strand template lesion skipping are competing bypass mechanisms.
J. Biol. Chem. 289(47) , 32811-23, (2014) A number of different enzymatic pathways have evolved to ensure that DNA replication can proceed past template base damage. These pathways include lesion skipping by the replisome, replication fork regression followed by either correction of the damage and or... |
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Levothyroxine replacement in hypothyroid humans reduces myocardial lipid load and improves cardiac function.
J. Clin. Endocrinol. Metab. 99(11) , E2341-6, (2014) Hypothyroidism is a common endocrine disorder frequently accompanied by alterations in lipid metabolism, such as hypercholesterolemia and high circulating triglycerides, both risk factors for nonischemic cardiomyopathy. Rodent studies suggest that the hypothy... |
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Mirolase, a novel subtilisin-like serine protease from the periodontopathogen Tannerella forsythia.
Biol. Chem. 396(3) , 261-75, (2015) The genome of Tannerella forsythia, an etiological factor of chronic periodontitis, contains several genes encoding putative proteases. Here, we characterized a subtilisin-like serine protease of T. forsythia referred to as mirolase. Recombinant full-length l... |
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Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.
Biochem. Pharmacol. 93(2) , 171-81, (2015) Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms of action at the molecular level are largely unknown. Howeve... |
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Infection of human amniotic and endothelial cells by Japanese encephalitis virus: Increased expression of HLA-F.
Virology 471-473 , 29-37, (2015) Productive infection of human amniotic and endothelial cell lines with Japanese encephalitis virus (JEV) was established leading to the induction of NFκB and HLA-F, a non-classical MHC molecule. Induction of the HLA-F gene and protein in JEV-infected cells wa... |
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Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.
J. Bacteriol. 197(5) , 819-32, (2015) Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine monophosphate (c-di-GMP) is a bacterial second messenger that typically regulates... |
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Bioengineering of bacteria to assemble custom-made polyester affinity resins.
Appl. Environ. Microbiol. 81(1) , 282-91, (2014) Proof of concept for the in vivo bacterial production of a polyester resin displaying various customizable affinity protein binding domains is provided. This was achieved by engineering various protein binding domains into a bacterial polyester-synthesizing e... |
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Glucocorticoid receptor binds half sites as a monomer and regulates specific target genes.
Genome Biol. 15(7) , 418, (2014) Glucocorticoid receptor (GR) is a hormone-activated, DNA-binding transcriptional regulatory factor that controls inflammation, metabolism, stress responses, and other physiological processes. In vitro, GR binds as an inverted dimer to a motif consisting of tw... |
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Uncovering a glycosyltransferase provides insights into the glycosylation step during macrolactin and bacillaene biosynthesis.
ChemBioChem. 15(18) , 2747-53, (2014) Macrolactins (MLNs) have unique structural patterns containing a 24-membered ring lactone and diverse bioactivities. The MLN skeleton is biosynthesized via a trans-acyl transferase (AT) type I polyketide synthase (PKS) pathway, but the tailoring steps are sti... |