Ketotifen fumarate
Ketotifen fumarate structure
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Common Name | Ketotifen fumarate | ||
|---|---|---|---|---|
| CAS Number | 34580-14-8 | Molecular Weight | 425.497 | |
| Density | 0.968 g/mL at 25 °C(lit.) | Boiling Point | 250-263 °C(lit.) | |
| Molecular Formula | C23H23NO5S | Melting Point | -43°C | |
| MSDS | Chinese USA | Flash Point | 96-98°C/5mm | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Development and validation of an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistaminics in dietary supplements.
Biomed. Chromatogr. 29(3) , 465-74, (2015) The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged fr... |
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[Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options].
Dtsch. Med. Wochenschr. 139(30) , 1523-34; quiz 1535-8, (2014) In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell... |
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The effect of antihistamines on seizures induced by increasing-current electroshocks: ketotifen, but not olopatadine, promotes the seizures in infant rats.
Biol. Pharm. Bull. 35(5) , 693-7, (2012) Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy. The purpose of this study was to investigate whether olopatadine, one of the most e... |
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Novel delivery approach for ketotifen fumarate: dissofilms formulation using 3² experimental design: in vitro/in vivo evaluation.
Pharm. Dev. Technol. 19(5) , 521-30, (2014) Orally dissolving films (dissofilms) have gained increasing popularity and attention due to their ease of administration and avoidance of first pass metabolism. Ketotifen fumarate (KF) bioavailability is reported to be only ~ 50% due to hepatic first-pass met... |
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Eosinophilic ascites resolution with ketotifen.
Mayo Clin. Proc. 86(10) , 1027, (2011)
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Mast cell stabilization: novel medication for obesity and diabetes.
Diabetes. Metab. Res. Rev. 27(8) , 919-24, (2011) Mast cells are essential in allergic responses and beyond. White adipose tissue from obese humans contains large numbers of mast cells. Serum mast cell tryptase levels are also significantly higher in obese subjects than in lean subjects, suggesting a role of... |
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Δ-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity.
Nat. Prod. Res. 26(23) , 2168-75, (2012) From cultures of thermophilic soil fungus Humicola grisea var thermoidea, a δ-lactam derivative (3-(2-(4-hydroxyphenyl)-2-oxoethyl)-5,6-dihydropyridin-2(1H)-one) that displayed anti-allergic activity was isolated, which was predicted by in silico computationa... |
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Carryover effect on next-day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial.
Hum. Psychopharmacol. Clin. Exp. 27(4) , 428-36, (2012) Antihistamines with strong sedative-hypnotic properties are frequently prescribed for insomnia secondary to allergy, but the potential risks of such administration have not been fully elucidated.This randomized, double-blind, placebo-controlled crossover stud... |
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Failure of omalizumab and successful control with ketotifen in a patient with vibratory angio-oedema.
Clin. Exp. Dermatol. 38(2) , 151-3, (2013) Vibratory angio-oedema is a rare form of physical urticaria characterized by pruriginous weals and angio-oedema at the site of exposure to vibration. Severe treatment-resistant disease can occur, and is associated with significant disability. Therapy with oma... |
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Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way.
Exp. Toxicol. Pathol. 65(3) , 229-34, (2013) Tityus serrulatus venom (Tsv)-induced pulmonary edema can occur in severe envenomation and the mechanisms involved are not completely understood. Therefore, we studied the effect of pharmacological modulation of the mast cell activation and the histamine anta... |