Nefopam hydrochloride
Nefopam hydrochloride structure
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Common Name | Nefopam hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 23327-57-3 | Molecular Weight | 289.800 | |
| Density | 1.064g/cm3 | Boiling Point | 369.5ºC at 760mmHg | |
| Molecular Formula | C17H20ClNO | Melting Point | N/A | |
| MSDS | Chinese | Flash Point | 109ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Nefopam and meperidine are infra-additive on the shivering threshold in humans.
Anesth. Analg. 119(1) , 58-63, (2014) Induction of therapeutic hypothermia is often complicated by shivering. Nefopam, a nonsedative benzoxazocine analgesic, reduces the shivering threshold (triggering core temperature) with minimal side effects. Consequently, nefopam is an attractive drug for in... |
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[Watch out for headaches at the end of a pregnancy! Do not miss an autoimmune hypositys].
Gynecol. Obstet. Fertil. 38(4) , 278-82, (2010) We report the case of a 21-year-old pregnant women (36 WA) presenting intensive headaches and visual disturbances. Those sellar compression symptoms have made us suppose the diagnosis of autoimmune hypophysitis. MRI has confirmed the typical aspect of symmetr... |
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Median effective dose (ED50) of paracetamol and nefopam for postoperative pain: isobolographic analysis of their antinociceptive interaction.
Minerva Anestesiol. 79(3) , 232-9, (2013) The analgesic efficacy of nefopam and of paracetamol has been shown in the postoperative period after mild- and moderate-pain surgery. The aim of this study was to define the median effective analgesic doses of each drug and of their combination, in order to ... |
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Nefopam after total hip arthroplasty: role in multimodal analgesia.
Orthop. Traumatol. Surg. Res. 99(2) , 169-74, (2013) Multimodal analgesia combining several non-opioid analgesics is recommended for pain control after surgery. In one study of total hip arthroplasty (THA), pain relief achieved by adding ketamine to the paracetamol-ketoprofen combination was statistically signi... |
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Usefulness of nefopam in treating pain of severe uncomplicated renal colics in adults admitted to emergency units: a randomised double-blind controlled trial. The 'INCoNU' study.
Emerg. Med. J. 30(2) , 143-8, (2013) Renal colic pain is a frequent cause of emergency department admissions (1-2% of admissions). It is extremely painful, often requiring intravenous morphine titration. The aim of this study was to estimate the effect of adding nefopam to ketoprofen upon subseq... |
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Nefopam enhances the protective activity of antiepileptics against maximal electroshock-induced convulsions in mice.
Pharmacol. Rep. 63(3) , 690-6, (2011) Nefopam is a centrally acting non-opioid analgesic with a mechanism of action that is not completely understood. Adverse effects associated with the therapeutic use and overdose of nefopam are mainly associated with the central nervous system, such as halluci... |
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Study of pharmacokinetics and comparative bioavailability of nefopam 30 mg tablets in twelve fasting healthy Pakistani male young subjects: single-dose, randomized, two-period, two-treatment and two-way cross-over design.
Med. Princ. Pract. 21(3) , 271-6, (2012) To study the pharmacokinetics and comparative bioavailability of nefopam tablets (Acupan®).Experimentation of this study was based on a single-dose, two-sequence, cross-over randomized design using 12 fasting healthy Pakistani male young subjects. This valida... |
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[Assessment of practices in postoperative analgesia in caesarean before and after implementation of an information program].
Ann. Fr. Anesth. Reanim. 32(6) , 402-8, (2013) To assess the improvement of practices in postoperative analgesia after a cesarean section post implementation of a corrective program.Prospective impact study.After obtaining ethics approval, we included all patients undergoing a cesarean section at Montpell... |
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Fatal nefopam overdose.
Emerg. Med. J. 27(5) , 407-8, (2010) Nefopam hydrochloride (Acupan) is a potent non-opioid analgesic widely used for the relief of moderate to severe postoperative pain. The drug is generally well tolerated, but it has a broad spectrum of side effects including tachycardia, sweating, nausea, sei... |
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Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report
Prog. Neuropsychopharmacol. Biol. Psychiatry 34(4) , 705-6, (2010)
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