Carbocisteine
Carbocisteine structure
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Common Name | Carbocisteine | ||
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| CAS Number | 638-23-3 | Molecular Weight | 179.194 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 417.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C5H9NO4S | Melting Point | 208-213 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | 206.2±28.7 °C | |
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
J. Med. Chem. 51 , 6740-51, (2008) The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr... |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.
Bioorg. Med. Chem. Lett. 17 , 3921-4, (2007) Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors. Some of these derivatives such as 4f demonstrated enhance... |
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A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics.
Biochem. Pharmacol. 81(8) , 1043-53, (2011) ThioTEPA, an alkylating agent with anti-tumor activity, has been used as an effective anticancer drug since the 1950s. However, a complete understanding of how its alkylating activity relates to clinical efficacy has not been achieved, the total urinary excre... |
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Disulphide linkage in mouse ST6Gal-I: determination of linkage positions and mutant analysis.
J. Biochem. 151(2) , 197-203, (2012) All cloned sialyltransferases from vertebrates are classified into four subfamilies and are characterized as having type II transmembrane topology. The catalytic domain has highly conserved motifs known as sialylmotifs. Besides sialylmotifs, each family has s... |
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S–carboxyethylcysteine (a constituent of Acacia seed) negatively affects casein protein utilization by rats
Nutrition 28(7-8) , 785-92, (2012) Objective Two rat bioassay experiments are reported. The first investigated the first limiting amino acid in Acacia colei and the second experiment investigated the effect of S-carboxyethylcysteine (CEC; a compound present in acacia seed) on protein use. |
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Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.
Amino Acids 44(2) , 361-71, (2013) Maillard reaction contributes to the chemical modification and cross-linking of proteins. This process plays a significant role in the aging process and determination of animal longevity. Oxidative conditions promote the Maillard reaction. Mitochondria are th... |
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An investigation into possible xenobiotic-endobiotic inter-relationships involving the amino acid analogue drug, S-carboxymethyl-L-cysteine and plasma amino acids in humans.
Amino Acids 42(5) , 1967-73, (2012) The amino acid derivative, S-carboxymethyl-L-cysteine, is an anti-oxidant agent extensively employed as adjunctive therapy in the treatment of human pulmonary conditions. A major biotransformation route of this drug, which displays considerable variation in c... |
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Recombinant heteromeric phenylalanine monooxygenase and the oxygenation of carbon and sulfur substrates.
J. Pharm. Pharmacol. 63(4) , 558-64, (2011) The aim of this investigation was to provide in-vitro enzyme kinetic data to support the hypothesis that the in-vivo heterozygous dominant phenotype for phenylalanine monooxygenase (hPAH) was responsible for the S-oxidation polymorphism in the metabolism of S... |
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A definite case of (L)-carbocisteine-induced pneumonia with CATCH22 syndrome.
Intern. Med. 52(1) , 97-100, (2013) A 32-year-old male with CATCH22 syndrome presented with a high fever and productive cough after taking drugs for acute bronchitis, including (L)-carbocisteine. Chest radiography revealed ground-glass opacities in the bilateral lung fields. He had a history of... |