Carbocisteine

Modify Date: 2024-01-02 12:12:36

Carbocisteine structure	Common Name	Carbocisteine
	CAS Number	638-23-3	Molecular Weight	179.194
	Density	1.5±0.1 g/cm3	Boiling Point	417.3±45.0 °C at 760 mmHg
	Molecular Formula	C₅H₉NO₄S	Melting Point	208-213 °C (dec.)
	MSDS	Chinese USA	Flash Point	206.2±28.7 °C

Use of Carbocisteine

Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD)[1].

Name	S-carboxymethyl-L-cysteine
Synonym	More Synonyms

Description	Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Paola Rogliani, et al. Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine. Respir Res. 2019 May 27;20(1):104.

Density	1.5±0.1 g/cm3
Boiling Point	417.3±45.0 °C at 760 mmHg
Melting Point	208-213 °C (dec.)
Molecular Formula	C₅H₉NO₄S
Molecular Weight	179.194
Flash Point	206.2±28.7 °C
Exact Mass	179.025223
PSA	125.92000
LogP	0.32
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.588
Water Solubility	SOLUBLE IN COLD WATER

Carbocisteine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY4342000

CHEMICAL NAME :: Alanine, 3-((carboxymethyl)thio)-, L-

CAS REGISTRY NUMBER :: 638-23-3

BEILSTEIN REFERENCE NO. :: 1725012

LAST UPDATED :: 199707

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H9-N-O4-S

MOLECULAR WEIGHT :: 179.21

WISWESSER LINE NOTATION :: QVYZ1S1VQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,1705,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,190,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10300 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,993,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,190,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1433 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,190,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11250 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,993,1981 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 625 mg/kg

SEX/DURATION :: female 17-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1311,1979

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	AY4342000
HS Code	2930909090

Precursor 10
CAS#:52-90-4 L-cysteine CAS#:3926-62-3 Sodium chloroacetate CAS#:64-69-7 Iodoacetic acid CAS#:56-89-3 L-Cystine
CAS#:10318-18-0 DL-Cysteine Hyd... CAS#:2731-73-9 3-Chloro-L-alanine CAS#:68-11-1 Mercaptoacetic acid CAS#:79-11-8 Chloroacetic acid
CAS#:5147-00-2 O-acetyl-L-serine CAS#:2150-55-2 UNII:48431VN59G
DownStream 3
CAS#:5472-74-2 L-Cysteine,N-be... CAS#:6332-29-2 L-Cysteine,N-be... CAS#:5439-87-2 L-Alanine,3-[(c...

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.

Toxicol. Mech. Methods 18 , 217-27, (2008)

ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifes...

Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

Bioorg. Med. Chem. Lett. 17 , 3921-4, (2007)

Inhibition of Eg5 represents a novel approach for the treatment of cancer. Here, we report the synthesis and structure-activity relationship of S-trityl-L-cysteine (STLC) derivatives as Eg5 inhibitors...

EINECS 211-327-5

Carbocysteine

MFCD00002614

Loviscol

Thiodril

Alanine, 3-((carboxymethyl)thio)-, L-

3-(Carboxymethylthio)-L-alanine

L-Carbocisteine

Muciclar

Fluifort

Mucocis

L-Cysteine, S- (carboxymethyl)-

S-Carboxymethylcysteine

3-[(Carboxymethyl)thio]-L-alanine

L-Cysteine, S-(carboxymethyl)-

carbocisteine

Carbocistein

Mucodyne

Transbronchin

Reomucil

S-(Carboxymethyl)-L-cysteine

Rhinathiol

S-Carboxymethyl-L-cysteine

Lisomucil

carbocisteine API

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Carbocisteine
Price: ￥108.0/1g ￥178.0/5g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Carbocysteine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S-Carboxymethyl-L-cysteine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: S-Carboxymethyl-L-Cysteine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Carbocistein
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: ￥700/100 mg

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Carbocisteine

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