Emetine dihydrochloride hydrate
Emetine dihydrochloride hydrate structure
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Common Name | Emetine dihydrochloride hydrate | ||
|---|---|---|---|---|
| CAS Number | 7083-71-8 | Molecular Weight | 571.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H40N2O4.2HCl.H2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B.
Sci. Rep. 5 , 16616, (2015) Aging is associated with impaired plasticity and memory. Altered epigenetic mechanisms are implicated in the impairment of memory with advanced aging. Histone deacetylase 3 (HDAC3) is an important negative regulator of memory. However, the role of HDAC3 in ag... |
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TDP-43 is recruited to stress granules in conditions of oxidative insult.
J. Neurochem. 111(4) , 1051-61, (2009) Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. TDP-43 is a DNA/RNA-binding protein ... |
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A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells.
Mol. Cancer Ther. 10(10) , 1818-28, (2011) Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a heterogeneous population of tumor cells among which a tumor-initiating and treatment-resistant subpopulation, here termed GBM stem cells, have been identified as primary therapeutic ... |
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Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43.
J. Biol. Chem. 285(1) , 608-19, (2010) TAR DNA-binding protein-43 (TDP-43) has been recently identified as a major component of the ubiquitinated inclusions found in frontotemporal lobar degeneration with ubiquitin-positive inclusions and in amyotrophic lateral sclerosis, diseases that are collect... |
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MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability.
Mol. Cell. Biol. 29(24) , 6380-90, (2009) As well as providing a structural framework, the actin cytoskeleton plays integral roles in cell death, survival, and proliferation. The disruption of the actin cytoskeleton results in the activation of the c-Jun N-terminal kinase (JNK) stress-activated prote... |
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eIF4E-binding proteins are differentially modified after ammonia versus intracellular calcium activation of sea urchin unfertilized eggs.
Mol. Reprod. Dev. 77(1) , 83-91, (2010) Fertilization of sea urchin eggs triggers a rise of protein synthesis mainly dependent on the cap-binding protein eIF4E, which is released from its repressor 4E-BP and associates with eIF4G. Association of eIF4G with eIF4E is a crucial event for the onset of ... |
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Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells.
Blood 114(19) , 4179-85, (2009) Premature termination codon (PTC) mutations are due to insertion or deletion of nucleotides causing a frameshift and premature termination codon in RNA. These transcripts are degraded by the nonsense-mediated decay pathway and have a very short half-life. We ... |
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TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transporters.
BMC Cancer 10 , 229, (2010) Exposure of cancer cells to chemotherapeutic agents may result in reduced sensitivity to structurally unrelated agents, a phenomenon known as multidrug resistance, MDR. The purpose of this study is to investigate cell growth inhibition of wild type and the co... |
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The cytotoxic effect of emetine and CGP-74514A studied with the hollow fiber model and ArrayScan assay in neuroendocrine tumors in vitro.
Anticancer Agents Med. Chem. 12(7) , 783-90, (2012) Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activi... |
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Human fascioliasis in Argentina: retrospective overview, critical analysis and baseline for future research.
Parasit. Vectors 4 , 104, (2011) In Argentina, human fascioliasis has never been adequately analysed, although having a physiography, climate, animal prevalences and lymnaeids similar to those of countries where the disease is endemic such as Bolivia, Peru and Chile. We performed a literatur... |