(S)-(-)-Bay K 8644
(S)-(-)-Bay K 8644 structure
|
Common Name | (S)-(-)-Bay K 8644 | ||
|---|---|---|---|---|
| CAS Number | 98625-26-4 | Molecular Weight | 356.29700 | |
| Density | 1.37g/cm3 | Boiling Point | 429.2ºC at 760mmHg | |
| Molecular Formula | C16H15F3N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 213.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Metformin as adjunct antituberculosis therapy.
Sci. Transl. Med. 6(263) , 263ra159, (2014) The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic drug metformin (MET) reduces the intracellular growth of Myc... |
|
|
Identification and mechanosensitivity of viscerofugal neurons.
Neuroscience 225 , 118-29, (2012) Enteric viscerofugal neurons are interneurons with cell bodies in the gut wall; they project to prevertebral ganglia where they provide excitatory synaptic drive to sympathetic neurons which control intestinal motility and secretion. Here, we studied the mech... |
|
|
[Participation of proteinkinase CK2 in regulation of human erythrocytes plasma membrane redox system activity: relative contribution of ca(2+)-dependent and ca(2+)-independent mechanisms of its activation].
Ukr. Biokhim. Zh. 84(5) , 55-61, (2012) Involvement of protein kinase CK2 (2.7.11.1) in modulation of live cells trans-plasma membrane electron transport was first discovered. Using human erythrocytes a decrease of plasma membrane redox system (PMRS) activity is shown under the action of specific p... |
|
|
Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation.
Am. J. Physiol. Cell Physiol. 296 , C1195-206, (2009) Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented and non-epithelial-shaped dedifferentiated intermediates. Because these dedifferentiated cells can either revert to pigmented epithelial cells o... |
|
|
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.
J. Mol. Cell. Cardiol. 52(5) , 998-1008, (2012) Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overall pro-arr... |
|
|
The effects of L type calcium channels on the electroencephalogram recordings in WAG/RIJ rat model of absence epilepsy.
Eur. Rev. Med. Pharmacol. Sci. 17(9) , 1149-54, (2013) Epilepsy is one of the most important central nervous system disorder and 1% of the total world population suffers from this disorder which require a chronic drug treatment. Most of the researchers suggested that excessive calcium entry into neurons is the ma... |
|
|
Vasodilation and hypotension of CZ454, an analogue of lacidipine through inhibiting extracellular calcium influx.
Arzneimittelforschung 62(9) , 439-45, (2012) The aim of this study was to evaluate the effects of an analogue of lacidipine, CZ454 in in vitro and in vivo. The isometric tension of Sprague-Dawley rat arterial ring segments was recorded by a myography system. Intracellular calcium of vascular smooth musc... |
|
|
An L-type calcium channel agonist, bay K8644, extends the window of intervention against ischemic neuronal injury.
Mol. Neurobiol. 47(1) , 280-9, (2013) Our previous data indicate that the inhibition of L-type calcium channels (LTCCs) might be the cause of post-ischemic neuronal injury and that the activation of LTCCs can give rise to neuroprotection. In the present study, we aimed to profile the intervention... |
|
|
The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.
J. Neurosci. 33(11) , 5006-16, (2013) In rodents, adrenergic signaling by norepinephrine (NE) in the hippocampus is required for the retrieval of intermediate-term memory. NE promotes retrieval via the stimulation of β1-adrenergic receptors, the production of cAMP, and the activation of both prot... |
|
|
Alpha2C-adrenoceptors play a prominent role in sympathetic constriction of porcine pulmonary arteries.
Naunyn Schmiedebergs Arch. Pharmacol. 385(6) , 595-603, (2012) Enhanced pulmonary vasoconstriction in response to injuries of the central nervous system and hypoxia result in pulmonary edema due to increased sympathetic activation. This study aimed to characterize α(2)-adrenoceptor (AR)-mediated responses in porcine pulm... |