L-(-)-Ephedrine
L-(-)-Ephedrine structure
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Common Name | L-(-)-Ephedrine | ||
|---|---|---|---|---|
| CAS Number | 299-42-3 | Molecular Weight | 165.232 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 255.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C10H15NO | Melting Point | 37-39 ℃(lit.) | |
| MSDS | Chinese USA | Flash Point | 85.6±0.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
J. Med. Chem. 48 , 3269-79, (2005) Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm of the partition coefficient of the neutral species in the... |
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A beating heart cell model to predict cardiotoxicity: effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine.
Food Chem. Toxicol. 78 , 207-13, (2015) Some dietary supplements may contain cardiac stimulants and potential cardiotoxins. In vitro studies may identify ingredients of concern. A beating human cardiomyocyte cell line was used to evaluate cellular effects following phenylethylamine (PEA), higenamin... |
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Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Bioorg. Med. Chem. 15 , 6943-55, (2007) A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set ... |
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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
J. Med. Chem. 49 , 3948-54, (2006) This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for ... |
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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
J. Med. Chem. 50 , 742-8, (2007) The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studies of toxic compounds, and in the cosmetics industry, is pre... |
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QSAR-based solubility model for drug-like compounds.
Bioorg. Med. Chem. 18 , 7078-84, (2010) Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemi... |
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Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Toxicol. Mech. Methods 18 , 217-27, (2008) ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the dev... |
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Dexmedetomidine reduces propofol and remifentanil requirements during bispectral index-guided closed-loop anesthesia: a double-blind, placebo-controlled trial.
Anesth. Analg. 118(5) , 946-55, (2014) The α2-adrenergic agonist dexmedetomidine is a sedative and can be used as an adjunct to anesthetics. Our primary goal was thus to determine the extent to which dexmedetomidine reduces the requirement for propofol and remifentanil.This double-blinded, randomi... |
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Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.
Molecules 17(11) , 12925-37, (2012) A high performance liquid chromatographic (HPLC) method with diode array detection (DAD) was established for simultaneous determination of seven main bioactive components in San-ao decoction and its series of formulae (San-ao decoction, Wu-ao decoction, Qi-ao... |