Piperine
Piperine structure
|
Common Name | Piperine | ||
|---|---|---|---|---|
| CAS Number | 94-62-2 | Molecular Weight | 285.338 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 498.5±40.0 °C at 760 mmHg | |
| Molecular Formula | C17H19NO3 | Melting Point | 131-135 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 255.3±27.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Piperine inhibits the growth and motility of triple-negative breast cancer cells.
Cancer Lett. 357(1) , 129-40, (2014) Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC ... |
|
|
Piperine from black pepper inhibits activation-induced proliferation and effector function of T lymphocytes.
J. Cell. Biochem. 116 , 2577-88, (2015) Piperine is a major alkaloid component of black pepper (Piper nigrum Linn), which is a widely consumed spice. Here, we investigated the effect of piperine on mouse T lymphocyte activation. Piperine inhibited polyclonal and antigen-specific T lymphocyte prolif... |
|
|
Development and validation of simultaneous estimation method for curcumin and piperine by RP-UFLC.
Pak. J. Pharm. Sci. 27(4) , 901-6, (2014) Curcumin and piperine are proven for their potent medicinal benefits to treat various diseases and they are most commonly used combination in various Indian systems of medicine such as Ayurveda, Siddha and Unani. The objective of the present work is to develo... |
|
|
Piperine, a natural bioenhancer, nullifies the antidiabetic and antioxidant activities of curcumin in streptozotocin-diabetic rats.
PLoS ONE 9(12) , e113993, (2014) Knowing that curcumin has low bioavailability when administered orally, and that piperine has bioenhancer activity by inhibition of hepatic and intestinal biotransformation processes, the aim of this study was to investigate the antidiabetic and antioxidant a... |
|
|
Investigation of the antibacterial activity and efflux pump inhibitory effect of co-loaded piperine and gentamicin nanoliposomes in methicillin-resistant Staphylococcus aureus.
Drug Dev. Ind. Pharm. 41 , 989-94, (2015) Antibiotic resistance has stimulated the research for developing novel strategies that can prevent bacterial growth. Methicillin-resistant Staphylococcus aureus (MRSA), regarded as one of the most serious antibiotic-resistant bacteria which has been conventio... |
|
|
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Bioorg. Med. Chem. 18 , 2225-31, (2010) There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability wi... |
|
|
Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide.
Arzneimittelforschung 62(8) , 384-8, (2012) Piperine (CAS no: 94-62-2), an alkaloid obtained from Piper nigrum and P. longum is a known inhibitor of various enzymes (CYP isozymes) responsible for biotransformation of drugs. By inhibiting the metabolism of drugs, piperine improves the bioavailability of... |
|
|
Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties.
Eur. J. Med. Chem. 43 , 1837-1846, (2008) The monoesters of curcumin, a symmetric diphenol with valine and glycine have been prepared by a novel solid phase synthesis and its diesters with valine, glutamic acid and demethylenated piperic acid have been prepared by solution phase method. The assessmen... |
|
|
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors
Bioorg. Med. Chem. 16 , 6689, (2008) Twenty-three heterocyclic compounds were evaluated for their potential as trypanothione reductase inhibitors. As a result, the harmaline, 10-thiaisoalloxazine, and aspidospermine frameworks were identified as the basis of inhibitors of Trypanosoma cruzi trypa... |
|
|
Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.
J. Infect. Dis. 210(3) , 456-66, (2014) Drug tolerance likely represents an important barrier to tuberculosis treatment shortening. We previously implicated the Mycobacterium tuberculosis efflux pump Rv1258c as mediating macrophage-induced tolerance to rifampicin and intracellular growth. In this s... |