2-Cyanoethyltetraisopropylphosphorodiamidite
2-Cyanoethyltetraisopropylphosphorodiamidite structure
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Common Name | 2-Cyanoethyltetraisopropylphosphorodiamidite | ||
|---|---|---|---|---|
| CAS Number | 102691-36-1 | Molecular Weight | 301.408 | |
| Density | 0.949 g/mL at 25 °C(lit.) | Boiling Point | 298.1±0.0 °C at 760 mmHg | |
| Molecular Formula | C15H32N3OP | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 177.9±28.4 °C | |
| Symbol |
GHS02, GHS08 |
Signal Word | Danger | |
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2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.
Nucleic Acids Res. 35(5) , 1441-51, (2007) The synthesis of oligonucleotides containing 2'-deoxy-2'-fluoro-4'-thioarabinonucleotides is described. 2'-Deoxy-2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU) was incorporated into 18-mer antisense oligonucleotides (AONs). 4'S-FMAU adopts a predominantl... |
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DNA adducts of acrolein: site-specific synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one, an acrolein adduct of guanine.
Chem. Res. Toxicol. 15(5) , 607-13, (2002) 3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one is formed in low yield by the reaction of acrolein with 2'-deoxyguanosine. The nucleoside and an oligodeoxynucleotide containing it have been synthesized. Fo... |
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Synthesis and fluorescence studies of multiple labeled oligonucleotides containing dansyl fluorophore covalently attached at 2'-terminus of cytidine via carbamate linkage.
Bioconjug. Chem. 15 , 638-646, (2004) Synthesis of modified oligonucleotides in which the specific cytidine nucleoside analogues linked at 2'-OH position via a carbamate bond with an amino ethyl derivative of dansyl fluorophore is reported. For the multiple labeling of oligonucleotides, a strateg... |
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Application of 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite for in situ preparation of deoxyribonucleoside phosphoramidites and their use in polymer-supported synthesis of oligodeoxyribonucleotides.
Nucleic Acids Res. 14(18) , 7391-403, (1986) Deoxyribonucleoside phosphoramidites are prepared in situ from 5'-O,N-protected deoxyribonucleosides and 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite with tetrazole as catalyst, and the solutions applied directly on an automatic solid-phase DNA syn... |
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Synthesis of 1,2-diacyl-sn-glycerophosphatidylserine from egg phosphatidylcholine by phosphoramidite methodology.
Lipids 31(5) , 541-6, (1996) A simple chemical method for the synthesis of 1,2-diacyl-sn-glycerophosphatidylserine (PS), with the same fatty acid composition in the sn-1 and sn-2 glycerol positions as egg phosphatidylcholine (PC), is described. PS synthesis was carried out by a phosphite... |
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LNA guanine and 2,6-diaminopurine. Synthesis, characterization and hybridization properties of LNA 2,6-diaminopurine containing oligonucleotides.
Bioorg. Med. Chem. 12 , 2385-2396, (2004) LNA guanine and 2,6-diaminopurine (D) phosphoramidites have been synthesized as building blocks for antisense oligonucleotides (ON). The effects of incorporating LNA D into ON were investigated. As expected, LNA D containing ON showed increased affinity towar... |
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Hexofuranosyl thymidines inserted into oligodeoxynucleotides via their two exocyclic hydroxy groups. Oligo synthesis and RNase H activity.
Bioorg. Med. Chem. 12 , 2843-2851, (2004) Hexofuranosyl nucleosides are considered as conformationally restricted acyclic nucleosides using a furanose ring to link the diol backbone to the nucleobase. The phosphoramidite of 1-(2,3-dideoxy-beta-D-erythro-hexofuranosyl)thymine was synthesized from thym... |
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Improved synthesis of (Pri2 N)2POCH2CH2CN.
Nucleic Acids Res. 15(8) , 3626, (1987)
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