Bretylium (tosylate)
Bretylium (tosylate) structure
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Common Name | Bretylium (tosylate) | ||
|---|---|---|---|---|
| CAS Number | 61-75-6 | Molecular Weight | 414.357 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H24BrNO3S | Melting Point | 97-99° | |
| MSDS | N/A | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Catecholamines, α-, and β-adrenoceptors are not responsible for activation of duodenum motility induced by sympathetic nerve stimulation.
Bull. Exp. Biol. Med. 152(1) , 5-8, (2011) Stimulation of sympathetic nerve in anesthetized dogs not treated with adrenergic blockers more frequently exerted stimulating rather than inhibitory effect on duodenal motility. Blockade of α- and β-adrenoceptors with phentolamine and propranolol, respective... |
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Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors.
J. Physiol. Pharmacol. 56(4) , 543-53, (2005) Pineal hormone melatonin is proposed as a potential treatment for severe sleep disturbances, and various gastrointestinal disorders. It was shown that melatonin increases intestinal motility and influences the activity of myoelectric complexes of the gut. The... |
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Tone of sympathetic nerves and regulation of heart activity.
Bull. Exp. Biol. Med. 130(10) , 930-3, (2000) Tone of sympathetic nerves to the heart was studied in rats and guinea pigs. Experiments with pharmacological blockade of the sympathetic nervous system and vagotomy confirmed the general notion on the absence of tonic effects of sympathetic nerves on the hea... |
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Localized abdominal pain following sympathetic blockade with bretylium for the management of complex regional pain syndrome.
Eur. J. Anaesthesiol. 19(2) , 147-8, (2002)
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Delayed threshold for active cutaneous vasodilation in patients with Type 2 diabetes mellitus.
J. Appl. Physiol. 100(2) , 637-41, (2006) Epidemiological evidence suggests decreased heat tolerance in patients with Type 2 diabetes mellitus (T2DM), but it is not known whether the mechanisms involved in thermoregulatory control of skin blood flow are altered in these patients. We tested the hypoth... |
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Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat.
Auton. Neurosci. 124(1-2) , 56-68, (2006) Evidence to date suggests that stress-induced exacerbation or relapse of intestinal inflammation in inflammatory bowel disease requires both activation of the autonomic nervous system and the activation of the immune system by the presence of previously encou... |
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Reflex haemodynamic responses caused by distension of the uterus in anaesthetized pigs.
J. Auton. Nerv. Syst. 63(1-2) , 1-11, (1997) The present study was undertaken in anaesthetized pigs to determine whether distension of the uterus reflexly affects the aortic blood pressure, heart rate, left ventricular inotropic state and the coronary circulation. Experiments were performed in 17 pigs a... |
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Baroreceptor modulation of active cutaneous vasodilation during dynamic exercise in humans.
J. Appl. Physiol. 90(4) , 1464-73, (2001) The hypothesis that baroreceptor unloading during dynamic limits cutaneous vasodilation by withdrawal of active vasodilator activity was tested in seven human subjects. Increases in forearm skin blood flow (laser-Doppler velocimetry) at skin sites with (contr... |
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Different vascular responses in glabrous and nonglabrous skin with increasing core temperature during exercise.
Eur. J. Appl. Physiol. 97(5) , 582-90, (2006) To elucidate the characteristics of vasomotor control in glabrous and nonglabrous skin during dynamic exercise, we compared the vascular responses in both areas to increasing core temperature during the cycle exercise for 30 min at different intensities in th... |
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Effect of age on cutaneous vasoconstrictor responses to norepinephrine in humans.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 287(5) , R1230-4, (2004) To test the hypothesis that cutaneous vasoconstrictor responsiveness to exogenous norepinephrine is reduced in older compared with young subjects, dose-response relations between norepinephrine and skin blood flow were established. Seven doses of norepinephri... |