Prazosin hydrochloride
Prazosin hydrochloride structure
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Common Name | Prazosin hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 19237-84-4 | Molecular Weight | 419.862 | |
| Density | N/A | Boiling Point | 638.4ºC at 760 mmHg | |
| Molecular Formula | C19H22ClN5O4 | Melting Point | 277 - 280 °C | |
| MSDS | Chinese USA | Flash Point | 339.9ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.
J. Pharmacol. Exp. Ther. 350(3) , 681-90, (2014) We previously found a negative inotropic (NIR) and positive lusitropic response (LR) to C-type natriuretic peptide (CNP) in the failing heart ventricle. In this study, we investigated and compared the functional responses to the natriuretic peptides (NPs), br... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Noradrenergic modulation of the parallel fiber-Purkinje cell synapse in mouse cerebellum.
Neuropharmacology 89 , 33-42, (2014) The signals arriving to Purkinje cells via parallel fibers are essential for all tasks in which the cerebellum is involved, including motor control, learning new motor skills and calibration of reflexes. Since learning also requires the activation of adrenerg... |
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A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis.
PLoS ONE 9(9) , e107146, (2014) CD248 (Endosialin) is a type 1 membrane protein involved in developmental and pathological angiogenesis through its expression on pericytes and regulation of PDGFRβ signalling. Here we explore the function of CD248 in skeletal muscle angiogenesis. Two distinc... |
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Prazosin Reduces Alcohol Intake in an Animal Model of Alcohol Relapse.
Alcohol. Clin. Exp. Res. 39 , 1538-46, (2015) Many alcoholics and heavy drinkers undergo repeated cycles of alcohol abstinence followed by relapse to alcohol drinking; a pattern that contributes to escalated alcohol intake over time. In rodents, alcohol drinking that is interspersed with periods of alcoh... |
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Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons.
Mol. Psychiatry 19(7) , 823-33, (2014) 3,4-Methylenedioxymethamphetamine (MDMA or 'ecstasy') is a psychostimulant drug, widely used recreationally among young people in Europe and North America. Although its neurotoxicity has been extensively described, little is known about its ability to strengt... |
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Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization.
Mol. Pharmacol. 88 , 347-56, (2015) There is ongoing debate about the role of G protein-coupled receptor kinases (GRKs) in agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present paper, we have used a novel membrane-permeable, small-molecule inhibitor of... |
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Uliginosin B, a natural phloroglucinol derivative, presents a multimediated antinociceptive effect in mice.
J. Pharm. Pharmacol. 66(12) , 1774-85, (2014) Investigate the involvement of monoaminergic and glutamatergic systems on the antinociceptive and ataxic effects of uliginosin B, which we have already demonstrated to be a promising molecular scaffold to develop new analgesic drugs.Uliginosin B was obtained ... |
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Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors.
J. Physiol. 592(Pt 19) , 4277-95, (2014) Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning. However, whether cellular correlates of brain plasticity ar... |