Dihydrocapsaicin
Dihydrocapsaicin structure
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Common Name | Dihydrocapsaicin | ||
|---|---|---|---|---|
| CAS Number | 19408-84-5 | Molecular Weight | 307.428 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 457.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H29NO3 | Melting Point | 62-65 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 230.4±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.
Life Sci. 92(6-7) , 368-78, (2013) Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of the present study was to know whether various vanilloids have... |
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Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.
J. Pharm. Biomed. Anal. 60 , 51-8, (2012) Capsaicinoids, salicylic acid, methyl and ethyl salicylate, glycol monosalicylate, camphor and l-menthol are widely used in topical formulations to relieve local pain. For each separate compound or simple mixtures, quantitative analysis methods are reported. ... |
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Increased susceptibility to cardiovascular effects of dihydrocapcaicin in resuscitated rats. Cardiovascular effects of dihydrocapsaicin.
BMC Cardiovasc. Disord. 10 , 39, (2010) Survivors of a cardiac arrest often have persistent cardiovascular derangements following cardiopulmonary resuscitation including decreased cardiac output, arrhythmias and morphological myocardial damage. These cardiovascular derangements may lead to an incre... |
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Acute effects of dihydrocapsaicin and capsaicin on the distribution of white blood cells in rats.
J. Nutr. Sci. Vitaminol. 55(3) , 282-7, (2009) The acute effects of dihydrocapsaicin (DHC) and capsaicin (CAP) on the number of white blood cells (WBCs), neutrophils, eosinophils, basophils, monocytes, lymphocytes, T lymphocytes, B lymphocytes and NK cells, and serum corticosterone levels were studied in ... |
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Antibacterial activity of Capsicum annuum extract and synthetic capsaicinoid derivatives against Streptococcus mutans.
J. Nat. Med. 66(2) , 354-6, (2012) The inhibitory effects of the ethyl acetate extract and capsaicin (1) and dihydrocapsaicin (2) isolated from fruits of Capsicum annuum chili pepper type, and synthetic capsaicinoid derivatives (N-(4-hydroxyphenylethyl)decamide (3), (E)-N-(4-hydroxy-3-methoxyb... |
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Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation.
Thromb. Res. 124(6) , 721-3, (2009)
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Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner.
Autophagy 4(8) , 1009-19, (2008) Although capsaicin, a pungent component of red pepper, is known to induce apoptosis in several types of cancer cells, the mechanisms underlying capsaicin-induced cytotoxicity are unclear. Here, we showed that dihydrocapsaicin (DHC), an analog of capsaicin, is... |
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Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(9) , R1040-50, (2013) Mild decrease of core temperature (32-34°C), also known as therapeutic hypothermia, is a highly effective strategy of neuroprotection from ischemia and holds significant promise in the treatment of stroke. However, induction of hypothermia in conscious stroke... |
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Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo.
J. Asian Nat. Prod. Res. 14(4) , 382-95, (2012) Capsaicin and dihydrocapsaicin, the two most abundant members of capsaicinoids in chili peppers, are widely used as food additives and for other purposes. In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, C... |