Dimethyl squarate
Dimethyl squarate structure
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Common Name | Dimethyl squarate | ||
|---|---|---|---|---|
| CAS Number | 5222-73-1 | Molecular Weight | 142.109 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 286.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C6H6O4 | Melting Point | 55-57 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 128.0±30.2 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice.
PLoS Negl. Trop. Dis. 9 , e0003881, (2015) Vibrio cholerae is the cause of cholera, a severe watery diarrhea. Protection against cholera is serogroup specific. Serogroup specificity is defined by the O-specific polysaccharide (OSP) component of lipopolysaccharide (LPS).Here we describe a conjugate vac... |
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Squaric acid-based peptidic inhibitors of matrix metalloprotease-1.
J. Org. Chem. 70(26) , 10792-802, (2005) [structure: see text] A series of squaric acid-peptide conjugates were synthesized and evaluated as inhibitors of MMP-1. The cyclobut-3-enedione core was substituted at the 3-position with several functional groups, such as -N(alkyl)OH, -NHOH, and -OH, that a... |
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Tetrahedron Lett. 34 , 6177, (1993)
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Hydroxylamin-Derivate der Quadratsäure. Zinner G, et al.
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Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.
Chem. Commun. (Camb.) 46(17) , 3004-6, (2010) Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees. |
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Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines.
Bioconjug. Chem. 22(10) , 2179-85, (2011) Bacterial O-SP-core antigens can be conjugated to proteins in the same, simple way as synthetic, linker-equipped carbohydrates by applying squaric acid chemistry. Introduction of spacers (linkers) to either O-SP-core antigens or protein carriers, which is inv... |
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Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide.
PLoS Negl. Trop. Dis. 8(2) , e2683, (2014) Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young childr... |