Chemical Communications 2010-05-07

Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.

Yong Qian, Gaoyuan Ma, Aifeng Lv, Hai-Liang Zhu, Jing Zhao, Viresh H Rawal

Index: Chem. Commun. (Camb.) 46(17) , 3004-6, (2010)

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Abstract

Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.