Nitidine chloride
Nitidine chloride structure
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Common Name | Nitidine chloride | ||
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| CAS Number | 13063-04-2 | Molecular Weight | 383.825 | |
| Density | 1.35g/cm3 | Boiling Point | 619ºC at 760 mmHg | |
| Molecular Formula | C21H18ClNO4 | Melting Point | 281-282ºC | |
| MSDS | Chinese USA | Flash Point | 189.4ºC | |
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Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway.
Int. J. Mol. Med. 32(1) , 79-84, (2013) Signal transducer and activator of transcription 3 (STAT3) is persistently activated in cancer cells and contributes to malignant progression in various types of cancer. The Janus-activated kinase (JAK) family phosphorylates STAT3 in response to stimulation b... |
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Alkaloids, amides and antispasmodic activity of Zanthoxylum hyemale.
Planta Med. 68(6) , 534-8, (2002) Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylu... |
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The role of the iminium bond in the inhibition of reverse transcriptase by quaternary benzophenanthridines.
J. Pharm. Pharmacol. 50(11) , 1307-15, (1998) The quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but their ability to bind with DNA by intercalation is believed ... |
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Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition.
Fitoterapia 81(8) , 1026-32, (2010) The inducing abilities of two alkaloids, Sanguinarine (San) and Nitidine (Nit), to fold human telomeric DNA d[5'-TTGGG(TTAGGG)(3)A-3'] (H24A) into G-quadruplex structures has been investigated by using CD and (1)H NMR spectroscopy. It is found that, under sal... |
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Development and validation of an LC-ESI-MS/MS method for the determination of nitidine chloride in rat plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 887-888 , 43-7, (2012) A new liquid chromatography-electrospray ionization-mass/mass spectrometry (LC-ESI-MS/MS) assay method has been developed and validated for the quantification of nitidine chloride (NC), an anti-cancer bioactive substance of Zanthoxylum nitidum (Roxb.) DC. pla... |
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DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors.
Biochemistry 37(8) , 2691-700, (1998) The ability of DNA topoisomerase I to mediate the formation of structurally modified DNA duplexes was studied utilizing suicide substrates containing high-efficiency cleavage sites and acceptor oligonucleotides in which the 5'-terminal nucleotides were varied... |
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Down-regulation of lipids transporter ABCA1 increases the cytotoxicity of nitidine.
Cancer Chemother. Pharmacol. 66(5) , 953-9, (2010) Nitidine (NTD) cytotoxicity is highly specific for A549 human lung adenocarcinoma cells. We hypothesized that this cytotoxicity involved the accumulation of NTD in intracellular organelles. However, there have been no reports of NTD transporting factors. In t... |
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The effect of nitidine chloride on the proliferation and apoptosis of nasopharyngeal carcinoma cells.
J. BUON 19(1) , 130-6, (2014) This study was conducted to investigate the effect of nitidine chloride (NC) on the proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE1, CNE2, TWO3, and C666-1, and to explore its antitumor mechanism.NC was dissolved in IMDM medium and cult... |
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Formal synthesis of nitidine and NK109 via palladium-catalyzed domino direct arylation/N-arylation of aryl triflates.
Org. Lett. 13(6) , 1486-9, (2011) The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically interesting benzo[c]p... |
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Gold(I)-catalyzed tandem reactions initiated by hydroamination of alkynyl carbamates: application to the synthesis of nitidine.
J. Org. Chem. 74(23) , 9158-64, (2009) As a convenient and direct synthesis of 1,2-dihydroisoquinolines, the gold(I)-catalyzed intramolecular hydroamination of (2-alkynyl)benzyl carbamates has been developed. The reaction with cationic gold(I) complex [AuCl(PPh(3))/AgNTf(2)] proceeded at room temp... |