Organic Letters 2011-03-18

Formal synthesis of nitidine and NK109 via palladium-catalyzed domino direct arylation/N-arylation of aryl triflates.

Mathieu Blanchot, David A Candito, Florent Larnaud, Mark Lautens

Index: Org. Lett. 13(6) , 1486-9, (2011)

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Abstract

The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically interesting benzo[c]phenanthridine alkaloids.